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Rheological studies indicate the formation of a strong gel found to be injectable and exhibit rapid self\u2010healing (within 10 min). The hydrogels also exhibited a high degree of swelling, suggesting potential as wound dressings since the absorption of large amounts of wound exudate, and optimum moisture levels, lead to accelerated wound healing. Andrographolide, an anti\u2010inflammatory natural product is used to fabricate silver nanoparticles, which are characterized and composited with the fabricated hydrogels to imbue them with anti\u2010microbial activity. The nanoparticle\/hydrogel composites exhibit activity against <jats:italic>Escherichia coli<\/jats:italic>, <jats:italic>Staphylococcus aureus<\/jats:italic>, and <jats:italic>Burkholderia pseudomallei<\/jats:italic>, the pathogen that causes melioidosis, a serious but neglected disease affecting southeast Asia and northern Australia. Finally, the nanoparticle\/hydrogel composites are shown to enhance wound closure in animal models compared to the hydrogel alone, confirming that these hydrogel composites hold great potential in the biomedical field.<\/jats:p>","DOI":"10.1002\/mabi.202300250","type":"journal-article","created":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T21:29:05Z","timestamp":1691098145000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["A Shear\u2010Thinning, Self\u2010Healing, Dual\u2010Cross Linked Hydrogel Based on Gelatin\/Vanillin\/Fe<sup>3+<\/sup>\/AGP\u2010AgNPs: Synthesis, Antibacterial, and Wound\u2010Healing Assessment"],"prefix":"10.1002","volume":"23","author":[{"given":"Chanon","family":"Talodthaisong","sequence":"first","affiliation":[{"name":"Materials Chemistry Research Center Department of Chemistry and Center of Excellence for Innovation in Chemistry Faculty of Science Khon Kaen University  Khon Kaen 40002 Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rina","family":"Patramanon","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Science Khon Kaen University  Khon Kaen 40002 Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saengrawee","family":"Thammawithan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Science Khon Kaen University  Khon Kaen 40002 Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarawut","family":"Lapmanee","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences Faculty of Medicine Siam University  Bangkok 10160 Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lamai","family":"Maikaeo","sequence":"additional","affiliation":[{"name":"Nuclear Technology Research and Development Center Thailand Institute of Nuclear Technology (Public Organization)  Nakhon Nayok 26120 Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phitchan","family":"Sricharoen","sequence":"additional","affiliation":[{"name":"Department of Premedical Science Faculty of Medicine, Bangkok Thonburi University  Thawi Watthana Bangkok 10170 Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattaka","family":"Khongkow","sequence":"additional","affiliation":[{"name":"National Nanotechnology Centre National Science and Technology Development Agency  Pathumthani 12120 Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katawut","family":"Namdee","sequence":"additional","affiliation":[{"name":"National Nanotechnology Centre National Science and Technology Development Agency  Pathumthani 12120 Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angkana","family":"Jantimaporn","sequence":"additional","affiliation":[{"name":"National Nanotechnology Centre National Science and Technology Development Agency  Pathumthani 12120 Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navaphun","family":"Kayunkid","sequence":"additional","affiliation":[{"name":"College of Materials Innovation and Technology King Mongkut's Institute of Technology Ladkrabang  Ladkrabang Bangkok 10520 Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Hutchison","sequence":"additional","affiliation":[{"name":"School of Chemistry and Centre of Excellence in Exciton Science The University of Melbourne  Parkville Victoria 3010 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2411-7495","authenticated-orcid":false,"given":"Sirinan","family":"Kulchat","sequence":"additional","affiliation":[{"name":"Materials Chemistry Research Center Department of Chemistry and Center of Excellence for Innovation in Chemistry Faculty of Science Khon Kaen University  Khon Kaen 40002 Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,16]]},"reference":[{"key":"e_1_2_9_1_1","volume":"1","author":"A\u00efssa B.","year":"2012","journal-title":"Adv. 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