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Therefore, the development of a dressing system that can be atraumatically removed from the wound bed can be considered a breakthrough and improve treatment times. In this work, the development of an injectable, fast\u2010gelling hydrogel is proposed that can change its mechanical properties when exposed to visible light. The hydrogels are prepared by a \u201cclick\u201d amino\u2010yne reaction between poly(ethylene glycol) (PEG) functionalized with propiolic acid and the amino groups of poly(ethyleneimine) (PEI). The hydrogels exhibit a fast gelation time, which can be adjusted by changing the weight percentage and molecular weight of the precursors. They also exhibit good swelling ability and adhesion to living tissues. More importantly, their mechanical properties changed upon irradiation with green light. This loss of properties is achieved by a <jats:sup>1<\/jats:sup>O<jats:sub>2<\/jats:sub>\u2010mediated mechanism, as confirmed by the degradation of the \u03b2\u2010aminoacrylate linker. Moreover, the in vitro cell compatibility results of the hydrogels and their degradation products show good cytocompatibility. Therefore, it is believed that these hydrogels can be considered as materials with great potential for an innovative strategy for the treatment of burn wounds.<\/jats:p>","DOI":"10.1002\/mabi.202300289","type":"journal-article","created":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T11:05:06Z","timestamp":1694948706000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Fast\u2010Gelling Polyethylene Glycol\/Polyethyleneimine Hydrogels Degradable by Visible\u2010Light"],"prefix":"10.1002","volume":"24","author":[{"given":"Carlos T.B.","family":"Paula","sequence":"first","affiliation":[{"name":"CEMMPRE Department of Chemical Engineering University of Coimbra  Rua S\u00edlvio Lima\u2010P\u00f3lo II Coimbra 3030\u2010790 Portugal"},{"name":"IPN, Instituto Pedro Nunes Associa\u00e7\u00e3o para a Inova\u00e7\u00e3o e Desenvolvimento em Ci\u00eancia e Tecnologia  Rua Pedro Nunes Coimbra 3030\u2010199 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