{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T02:35:52Z","timestamp":1785551752669,"version":"3.56.0"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T00:00:00Z","timestamp":1699920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T00:00:00Z","timestamp":1699920000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Nanofibrous scaffolds have attracted much attention in bladder reconstruction approaches due to their excellent mechanical properties. In addition, their biological properties can be improved by combination with biological materials. Taking into account the advantages of nanofibrous scaffolds and decellularized extracellular matrix (dECM) in tissue engineering, scaffolds of poly\u2011L\u2011lactic acid (PLLA) coated with decellularized human amnion membrane (hAM) or sheep bladder (SB)\u2010derived ECM proteins are developed (amECM\u2010coated PLLA and sbECM\u2010coated PLLA, respectively). The bladder regenerative potential of modified electrospun PLLA scaffolds is investigated in rabbits. The presence of ECM proteins is confirmed on the nanofibers\u2019 surface. Coating the surface of the PLLA nanofibers improves cell adhesion and proliferation. Histological and immunohistochemical evaluations show that rabbits subjected to cystoplasty with a multilayered PLLA scaffold show de novo formation and maturation of the multilayered urothelial layer. However, smooth muscle bundles (myosin heavy chain [MHC] and \u03b1\u2010smooth muscle actin [\u03b1\u2010SMA] positive) are detected only in ECM\u2010coated PLLA groups. All groups show no evidence of a diverticulumor fistula in the urinary bladder. These results suggest that the biofunctionalization of electrospun PLLA nanofibers with ECM proteins can be a promising option for bladder tissue engineering. Furthermore, hAM can also replace animal\u2010sourced ECM proteins in bladder tissue regeneration approaches.<\/jats:p>","DOI":"10.1002\/mabi.202300308","type":"journal-article","created":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T15:59:06Z","timestamp":1699286346000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["RETRACTED: The Effect of Multilayered\u00a0Electrospun PLLA Nanofibers Coated with Human Amnion or Bladder ECM Proteins on Epithelialization and Smooth Muscle Regeneration in the Rabbit Bladder"],"prefix":"10.1002","volume":"24","author":[{"given":"Keykavoos","family":"Gholami","sequence":"first","affiliation":[{"name":"Urology Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehsan","family":"Seyedjafari","sequence":"additional","affiliation":[{"name":"Department of Biotechnology College of Science University of Tehran Tehran 1416753955 Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh Sadat","family":"Mahdavi","sequence":"additional","affiliation":[{"name":"Department of Biotechnology College of Science University of Tehran Tehran 1416753955 Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Naghdipoor","sequence":"additional","affiliation":[{"name":"Urology Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gholamreza","family":"Mesbah","sequence":"additional","affiliation":[{"name":"Urology Research Center Tehran University of Medical Sciences  Tehran Iran"},{"name":"AshianGanoTeb Biopharmaceutical Company Golestan University of Medical Sciences Gorgan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parisa","family":"Zahmatkesh","sequence":"additional","affiliation":[{"name":"Urology Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milad","family":"Akbarzadehmoallemkolaei","sequence":"additional","affiliation":[{"name":"Animal Model Integrated Network (AMIN) Universal Scientific Education and Research Network (USERN)  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila Zareian","family":"Baghdadabad","sequence":"additional","affiliation":[{"name":"Urology Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiv Kumar","family":"Pandian","sequence":"additional","affiliation":[{"name":"Chelsea and Westminster Hospital NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirolos N","family":"Meilika","sequence":"additional","affiliation":[{"name":"Urology Service Department of Surgery Memorial Sloan Kettering Cancer Center  New York NY 1416753955 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1611-0362","authenticated-orcid":false,"given":"Seyed Mohammad Kazem","family":"Aghamir","sequence":"additional","affiliation":[{"name":"Urology Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,14]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.11.046"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.5173\/ceju.2013.03.art7"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68438-9"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surge.2017.07.002"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/21691401.2014.922568"},{"key":"e_1_2_10_6_1","volume":"4","author":"Gizaw M.","year":"2019","journal-title":"Med. 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