{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T17:04:44Z","timestamp":1785431084616,"version":"3.56.0"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T00:00:00Z","timestamp":1697932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T00:00:00Z","timestamp":1697932800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study focuses on creating a specialized nanogel for targeted drug delivery in cancer treatment, specifically targeting prostate cancer. This nanogel (referred to as SGK 636\/Peptide 563\/PEtOx nanogel) is created using hydrophilic poly(2\u2010ethyl\u20102\u2010oxazoline) (PEtOx) through a combination of living\/cationic ring\u2010opening polymerization (CROP) and alkyne\u2010azide cycloaddition (CuAAC) \u201cclick\u201d chemical reactions. A fluorescent probe (BODIPY) is also conjugated with the nanogel to monitor drug delivery. The characterizations through\n                    <jats:sup>1<\/jats:sup>\n                    H\u2010NMR, and FT\u2010IR, SEM, TEM, and DLS confirm the successful production of uniform, and spherical nanogels with controllable sizes (100 to 296\u00a0nm) and stability in physiological conditions. The biocompatibility of nanogels is evaluated using MTT cytotoxicity assays, revealing dose\u2010dependent cytotoxicity. Drug\u2010loaded nanogels exhibited significantly higher cytotoxicity against cancer cells in vitro compared to drug\u2010free nanogels. Targeting efficiency is examined using both peptide\u2010conjugated and peptide\u2010free nanogels, with the intracellular uptake of peptide 563\u2010conjugated nanogels by tumor cells being 60\u2010fold higher than that of nanogels without the peptide. The findings suggest that the prepared nanogel holds great potential for various drug delivery applications due to its ease of synthesis, tunable functionality, non\u2010toxicity, and enhanced intracellular uptake in the tumor region.\n                  <\/jats:p>","DOI":"10.1002\/mabi.202300324","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T19:44:40Z","timestamp":1697139880000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Novel PEtOx\u2010Based Nanogel Targeting Prostate Cancer Cells for Drug Delivery"],"prefix":"10.1002","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2576-3085","authenticated-orcid":false,"given":"Sevgi","family":"G\u00fcly\u00fcz","sequence":"first","affiliation":[{"name":"Material Technologies Marmara Research Center TUBITAK  Gebze Kocaeli 41470 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6233-9574","authenticated-orcid":false,"given":"Melike","family":"Sessevmez","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology Istanbul University  Istanbul 34116 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1896-8987","authenticated-orcid":false,"given":"Gokcen","family":"Ukuser","sequence":"additional","affiliation":[{"name":"Material Technologies Marmara Research Center TUBITAK  Gebze Kocaeli 41470 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5402-0467","authenticated-orcid":false,"given":"Melek Parlak","family":"Khalily","sequence":"additional","affiliation":[{"name":"Department of Basic Science and Health Cannabis Research Institute Yozgat Bozok University  Yozgat 66100 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2940-7678","authenticated-orcid":false,"given":"Selen","family":"Tiryaki","sequence":"additional","affiliation":[{"name":"Department of Genetics and Bioengineering Yeditepe University  Istanbul 34755 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2250-2143","authenticated-orcid":false,"given":"Tarik","family":"Sipahioglu","sequence":"additional","affiliation":[{"name":"Department of Genetics and Bioengineering Yeditepe University  Istanbul 34755 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3963-4687","authenticated-orcid":false,"given":"Kaan","family":"Birg\u00fcl","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry School of Pharmacy Bah\u00e7e\u015fehir University  Be\u015fikta\u015f Istanbul 34353 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130pek","family":"\u00d6mero\u011flu","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Gebze Technical University  Gebze Kocaeli 41400 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5981-1391","authenticated-orcid":false,"given":"Salih","family":"\u00d6z\u00e7ubuk\u00e7u","sequence":"additional","affiliation":[{"name":"Department of Chemistry Middle East Technical University  Ankara 06800 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2793-6533","authenticated-orcid":false,"given":"Dilek","family":"Telci","sequence":"additional","affiliation":[{"name":"Department of Genetics and Bioengineering Yeditepe University  Istanbul 34755 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9405-8905","authenticated-orcid":false,"given":"\u015e. 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