{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:34:45Z","timestamp":1787499285725,"version":"build-2736575974"},"reference-count":51,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T00:00:00Z","timestamp":1702425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2021K1A3A1A12103299"],"award-info":[{"award-number":["2021K1A3A1A12103299"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2021R1A4A2001827"],"award-info":[{"award-number":["2021R1A4A2001827"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2020K1A3A1A19088488"],"award-info":[{"award-number":["2020K1A3A1A19088488"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002543","name":"Pusan National University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Cerebrospinal fluid (CSF) leakage is a common complication of intradural surgery or incidental durotomy in neurosurgery. Dural suturing is a common method for durotomy repair, but this technique requires a long operation time and includes the risk of CSF leakage by incomplete sealing. Glue\u2010type sealants are effective for watertight dural closure. However, unresolved shortcomings include insufficient sealing performance, poor biocompatibility, and excessive swelling. Here, a dural sealant using light\u2010activated hyaluronic acid (HA) with multi\u2010networks (HA photosealant) that provides fast sealing performance and high biocompatibility is reported. The HA photosealants form a watertight hydrogel barrier with multilength networks under low\u2010energy visible light exposure (405\u00a0nm, &lt;1\u00a0J\u00a0cm\n                    <jats:sup>\u22122<\/jats:sup>\n                    ) for 5\u00a0s and allow firm tissue adhesion on the wet dural surface. In a rabbit model of craniectomy and durotomy, HA photosealants exhibit the faster sealing performance of dural tears and enhance dural repair with accelerated bone formation compared to commercial surgical glues, with no degenerative changes, such as inflammation or necrosis, in histopathological evaluation. This biocompatible HA photosealant can be applied in a variety of clinical settings that require fast wound closure as a promising potential.\n                  <\/jats:p>","DOI":"10.1002\/mabi.202300359","type":"journal-article","created":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T20:29:02Z","timestamp":1701116942000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Enhanced Dural Repair Using Biodegradable Sealants Based on Photocurable Hyaluronic Acid"],"prefix":"10.1002","volume":"24","author":[{"given":"Hyeseon","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Biomaterials Science (BK21 Four Program) Life and Industry Convergence Institute Pusan National University  Miryang 50463 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Preclinical Research Center Daegu\u2010Gyeongbuk Medical Innovation Foundation  Daegu 41061 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keum\u2010Yong","family":"Seong","sequence":"additional","affiliation":[{"name":"Department of Biomaterials Science (BK21 Four Program) Life and Industry Convergence Institute Pusan National University  Miryang 50463 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subin","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Biomaterials Science (BK21 Four Program) Life and Industry Convergence Institute Pusan National University  Miryang 50463 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min\u2010Soo","family":"Seo","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Kyunpook National University  Daegu 41566 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su Ryon","family":"Shin","sequence":"additional","affiliation":[{"name":"Division of Engineering in Medicine Department of Medicine Harvard Medical School Brigham and Women's Hospital  Cambridge MA 02139 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoung Hyup","family":"Nam","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Medical Research Institute Pusan National University Hospital Pusan National University School of Medicine  Busan 49241 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1233-8960","authenticated-orcid":false,"given":"Seung Yun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Biomaterials Science (BK21 Four Program) Life and Industry Convergence Institute Pusan National University  Miryang 50463 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,13]]},"reference":[{"key":"e_1_2_8_1_1","first-page":"270","volume":"19","author":"Miranda\u2010Filho A.","year":"2017","journal-title":"Neuro\u2010Oncology"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30468-X"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21693"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.04.042"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599811411534"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surneu.2005.03.041"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3171\/2009.10.SPINE09537"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2741\/4182"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ons\/opx260"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/17434440.2019.1626232"},{"key":"e_1_2_8_11_1","first-page":"232","volume":"62","author":"Nainan G. K.","year":"2014","journal-title":"J. Assoc. Physicians India"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2021.118752"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2009.04.057"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-019-0169-1"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smaim.2021.11.004"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.7b00969"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202200874"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202201578"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-019-0171-7"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-011-2071-z"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3171\/2013.8.SPINE12998"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2018.02.013"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2019.12.035"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/btm2.10323"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1116\/1.5095886"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2560\/8\/4\/046033"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2019.10.169"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2015.08.061"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2006.11.050"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1515\/ntrev-2020-0084"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5162394"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2003.033126"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-02752-6.50015-8"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-7020-4762-6.00005-9"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-39316-4.00001-6"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e31818d5427"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e3181b9fc45"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.cr2013-0010"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2011.0427"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2019.110411"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2013.09.005"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/2055-7124-18-8"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.5999\/aps.2015.42.2.232"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jctube.2017.02.001"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-012-1744-6"},{"key":"e_1_2_8_46_1","first-page":"51","volume":"14","author":"Mazgajczyk E.","year":"2012","journal-title":"Acta Bioeng. Biomech."},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep27474"},{"key":"e_1_2_8_48_1","first-page":"297","volume":"19","author":"Velnar T.","year":"2019","journal-title":"Bosnian J. Basic Med. Sci."},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.13004\/kjnt.2014.10.2.76"},{"key":"e_1_2_8_50_1","first-page":"216","volume":"46","author":"Lee H.","year":"2022","journal-title":"Polymer"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2023.04.031"}],"container-title":["Macromolecular Bioscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mabi.202300359","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T10:56:25Z","timestamp":1713178585000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mabi.202300359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,13]]},"references-count":51,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1002\/mabi.202300359"],"URL":"https:\/\/doi.org\/10.1002\/mabi.202300359","archive":["Portico"],"relation":{},"ISSN":["1616-5187","1616-5195"],"issn-type":[{"value":"1616-5187","type":"print"},{"value":"1616-5195","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,13]]},"assertion":[{"value":"2023-08-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2300359"}}