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Thus, ROS\u2010responsive polymers with inherent ROS scavenging activity and biodegradability are extremely needed for the efficient treatment of ROS\u2010related diseases. Here, this work fabricates the amphiphilic diblock copolymer PEG\u2010b\u2010PBC via ring\u2010opening polymerization (ROP) of phenylboronic acid ester conjugated cyclic carbonate monomer. The copolymer easily forms micelles (BCM) and scavenges ROS rapidly. BCM not only releases the delivered drug but degrades to produce the small molecules p\u2010hydroxybenzyl alcohol (HBA) with anti\u2010inflammatory capability in the presence of H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>. BCM can reduce the oxidative stress of human umbilical vein endothelial cells (HUVEC) and the levels of inflammatory factors secreted by macrophages, showing antioxidative and anti\u2010inflammatory activity. Finally, BCM exerts a significant capability to reduce the complications of inflammation and thrombosis in vivo. The biodegradable aliphatic poly(carbonate)s have the potential to be used for drug delivery systems (DDS) for diseases induced by reactive oxygen species.<\/jats:p>","DOI":"10.1002\/mabi.202300409","type":"journal-article","created":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T18:28:28Z","timestamp":1700245708000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["H<sub>2<\/sub>O<sub>2<\/sub>\u2010Responsive Polymeric Micelles of Biodegradable Aliphatic Poly(carbonate)s as Promising Therapeutic Agents for Inflammatory Diseases"],"prefix":"10.1002","volume":"24","author":[{"given":"Runhai","family":"Chen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences  Changchun Jilin 130022 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Xia","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences  Changchun Jilin 130022 China"},{"name":"University of Science and Technology of China  Hefei Anhui 230026 P. 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