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Polycaprolactone (PCL) is a biodegradable polymer widely explored for application in corneal reconstruction due to its excellent mechanical properties, biocompatibility, easy processability, and flexibility. In this study, a PCL\/collagen composite membrane with reinforced mechanical properties is developed. The membrane has a strong composite structure with collagen by utilizing a porous and hydrophilic PCL scaffold, maintaining its integrity even after immersion. The suture retention and mechanical tests demonstrate that compared with the pure collagen membrane, the prepared membrane has a greater tensile strength and twice the modulus of elasticity. Further, the suture retention strength is improved by almost two times. In addition, the membrane remains fully intact on the implant bed in an in vitro corneal defect model. Moreover, the membrane can be tightly sutured to a rabbit corneal defect, progressively achieve epithelialization, and remain unchanged during observation. Overall, the PCL\/collagen composite membrane is a promising candidate as a suturable corneal restoration material in clinical keratoplasty.<\/jats:p>","DOI":"10.1002\/mabi.202300449","type":"journal-article","created":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T07:23:20Z","timestamp":1704439400000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Hydrophilic, Porous, Fiber\u2010Reinforced Collagen\u2010Based Membrane for Corneal Repair"],"prefix":"10.1002","volume":"24","author":[{"given":"Zhi\u2010Biao","family":"Li","sequence":"first","affiliation":[{"name":"School of Materials Science and Engineering South China University of Technology  Guangzhou 510006 P. R. China"},{"name":"National Engineering Research Center for Tissue Restoration and Reconstruction South China University of Technology  Guangzhou 510006 P. R. 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