{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:09:23Z","timestamp":1791310163085,"version":"4.3.1"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T00:00:00Z","timestamp":1702339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["FL220100016"],"award-info":[{"award-number":["FL220100016"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The global increase in invasive fungal infections and the emergence of drug\u2010resistant strains demand the urgent development of novel antifungal drugs. In this context, synthetic polymers with diverse compositions, mimicking natural antimicrobial peptides, have shown promising potential for combating fungal infections. This study investigates how altering polymer end\u2010groups and topology from linear to branched star\u2010like structures affects their efficacy against\n                    <jats:italic>Candida<\/jats:italic>\n                    spp., including clinical isolates. Additionally, the polymers\u2019 biocompatibility is accessed with murine embryonic fibroblasts and red blood cells in\u00a0vitro. Notably, a low\u2010molecular weight star polymer outperforms both its linear polymeric counterparts and amphotericin B (AmpB)\u00a0in terms of an improved therapeutic index and reduced haemolytic activity, despite a higher minimum inhibitory concentration against\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    (\n                    <jats:italic>C. albicans<\/jats:italic>\n                    ) SC5314 (16\u201332\u00a0\u00b5g\u00a0mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    vs 1\u00a0\u00b5g\u00a0mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    for AmpB). These findings demonstrate the potential of synthetic polymers with diverse topologies as promising candidates for antifungal applications.\n                  <\/jats:p>","DOI":"10.1002\/mabi.202300452","type":"journal-article","created":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T19:19:26Z","timestamp":1701112766000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Effect of Star Topology Versus Linear Polymers on Antifungal Activity and Mammalian Cell Toxicity"],"prefix":"10.1002","volume":"24","author":[{"given":"Sebastian","family":"Schaefer","sequence":"first","affiliation":[{"name":"School of Chemical Engineering University of New South Wales (UNSW)  Sydney New South Wales 2052 Australia"},{"name":"Australian Centre for NanoMedicine UNSW  Sydney New South Wales 2052 Australia"},{"name":"School of Biotechnology and Biomolecular Sciences UNSW  Sydney New South Wales 2052 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