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To this purpose, a biobased, biocompatible, and photo\u2010curable resin made of acrylated epoxidized soybean oil (AESO) diluted with soybean oil (SO) is developed and 3D printed using a commercial digital light processing (DLP) 3D printer. 3D printed samples show good thermal properties, allowing for thermally\u2010based sterilization process and mechanical properties typical of crosslinked natural oils (i.e., <jats:italic>E<\/jats:italic> = 12\u00a0MPa, UTS = 1.5\u00a0MPa), suitable for the GBR application in the oral surgery. The AESO\u2010SO bio\u2010resin proves to be cytocompatible, allowing for fibroblast cells proliferation (viability at 72\u00a0h &gt; 97%), without inducing severe inflammatory response when co\u2010cultured with macrophages, as demonstrated by cytokine antibody arrays, that is anyway resolved in the first 24 h. Moreover, accelerated degradation tests prove that the bio\u2010resin is biodegradable in hydrolytic environments.<\/jats:p>","DOI":"10.1002\/mabi.202300458","type":"journal-article","created":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T00:38:22Z","timestamp":1704933502000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Soybean Oil\u2010Based 3D Printed Mesh Designed for Guided Bone Regeneration (GBR) in Oral Surgery"],"prefix":"10.1002","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5921-0884","authenticated-orcid":false,"given":"Mario","family":"Bragaglia","sequence":"first","affiliation":[{"name":"Department of Enterprise Engineering University of Rome \u201cTor Vergata\u201d  Via del Politecnico 1 Rome 00133 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Sciarretta","sequence":"additional","affiliation":[{"name":"IRCCS  Fondazione Santa Lucia Rome 00179 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierfrancesco","family":"Filetici","sequence":"additional","affiliation":[{"name":"Multispecialty Department of Oral Surgery \u2013 Periodontology and Implant\u2010Prosthodontic Rehabilitation Universit\u00e0 Cattolica del Sacro Cuore  Largo F. 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