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However, the codelivery of drugs with diverse physicochemical properties in a single formulation remains a formidable challenge. Here, microcapsules are designed based on hydroxyethyl starch\u2013curcumin (HES\u2500CUR) conjugates to enable the simultaneous delivery of hydrophobic dexamethasone acetate (DA) and hydrophilic cefazolin sodium (CS), yielding multiple drug\u2010loaded microcapsules (CS\/DA\u2010loaded HES\u2500CUR microcapsules, CDHC\u2010MCs) tailored for colon\u2010targeted therapy of UC. Thorough characterization confirms the successful synthesis and exceptional biocompatibility of CDHC\u2010MCs. Biodistribution studies demonstrate that the microcapsules exhibit an impressive inflammatory targeting effect, accumulating preferentially in inflamed colons. In vivo experiments employing a dextran\u2010sulfate\u2010sodium\u2010induced UC mouse model reveal that CDHC\u2010MCs not only arrest UC progression but also facilitate the restoration of colon length and alleviate inflammation\u2010related splenomegaly. These findings highlight the potential of colon\u2010targeted delivery of multiple drugs within a single formulation as a promising strategy to enhance UC treatment, and the CDHC\u2010MCs developed in this study hold great potential in developing novel oral formulations for advanced UC therapy.<\/jats:p>","DOI":"10.1002\/mabi.202300465","type":"journal-article","created":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T08:30:33Z","timestamp":1702974633000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Colon\u2010Targeted Oral Delivery of Hydroxyethyl Starch\u2013Curcumin Microcapsules Loaded with Multiple Drugs Alleviates DSS\u2010Induced Ulcerative Colitis in Mice"],"prefix":"10.1002","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3621-5233","authenticated-orcid":false,"given":"Da","family":"Huang","sequence":"first","affiliation":[{"name":"College of Biological Science and Engineering 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