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The physicochemical properties of nanoparticles are characterized by scanning electron microscopy, Fourier transform infrared, dynamic light scattering, thermogravimetric\/differential scanning calorimetry, and X\u2010ray diffraction. In vitro drug release at different temperatures and pH values is examined to ascertain the release pattern of two drugs, which can be well described by Korsmeyer\u2013Peppas kinetic model. The cytotoxicity evaluation illustrates that the tumor cells could be more effectively killed by the drug\u2010loaded nanoparticles, and the improved therapeutic effect is attributed to the controllable and sustainable drug release as well as the enhanced cellular uptake. The blood safety and good biocompatibility of nanoparticles are further confirmed by hemolysis assay, indicating the prepared nanoparticles are potential candidates for effective tumor treatment.<\/jats:p>","DOI":"10.1002\/mabi.202300469","type":"journal-article","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T11:20:19Z","timestamp":1704885619000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Preparation of PMMA\u2010Based Temperature\/pH Responsive Nanoparticles Encapsulating 5\u2010Fluorouracil and Methotrexate In Situ by One\u2010Pot Dispersion Photopolymerization"],"prefix":"10.1002","volume":"24","author":[{"given":"Siyuan","family":"Yu","sequence":"first","affiliation":[{"name":"School of Chemical Engineering and Technology Tianjin University  Tianjin 300350 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian","family":"Shao","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Hormones and Development Tianjin Key Laboratory of Metabolic Diseases Chu Hsien\u2010I Memorial Hospital and Tianjin Institute of Endocrinology Tianjin Medical University  Tianjin 300134 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tong","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering and Technology Tianjin University  Tianjin 300350 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering and Technology Tianjin University  Tianjin 300350 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6137-5824","authenticated-orcid":false,"given":"Pei","family":"Yu","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Hormones and Development Tianjin Key Laboratory of Metabolic Diseases Chu Hsien\u2010I Memorial Hospital and Tianjin Institute of Endocrinology Tianjin Medical University  Tianjin 300134 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4633-2804","authenticated-orcid":false,"given":"Jinfeng","family":"Xing","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering and Technology Tianjin University  Tianjin 300350 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,12]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canrad.2019.08.004"},{"key":"e_1_2_8_2_1","volume":"11","author":"Moodley T.","year":"2021","journal-title":"Biointerface Res. 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