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To date, the selection of anticoagulants has focused on mechanisms inhibiting white, but not red (erythrocytes) thrombus formation. In the present study, polyethersulfone (PES) membranes are modified with the antioxidant drug tiopronin; the physicochemical properties and dialysis performance of the Tio\u2010PES membranes are evaluated. The effects on erythrocyte thrombosis are evaluated in terms of erythrocyte morphology, prothrombotic properties (adhesion, aggregation, viscosity, sedimentation, and hemolysis), and fibrinogen (FIB)\u2010erythrocyte interactions. The regular anticoagulant and antiplatelet properties are also assessed. Superoxide dismutase, malondialdehyde, plasma protein, and complement C3a are further determined. Finally, the biosafety of the Tio\u2010PES membranes is evaluated both in vitro and in vivo. The Tio\u2010PES membranes exhibit excellent physicochemical properties and improved dialysis performance. It is found that the Tio\u2010PES membranes stabilize erythrocyte morphology, reduce erythrocyte prothrombotic properties, decrease FIB adsorption, and prevent red thrombus formation. In addition, the Tio\u2010PES membranes exhibit excellent antioxidant properties and show biosafety in primary toxicity studies. Thus, Tio\u2010PES membranes hold promise as novel, safe, and effective dialysis materials for potential clinical application.<\/jats:p>","DOI":"10.1002\/mabi.202300496","type":"journal-article","created":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T21:18:30Z","timestamp":1708031910000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Preparation and Hemocompatibility of Novel Antioxidant\u2010Modified Polyethersulfone Membranes as Red Blood Cell Thrombosis Inhibitors"],"prefix":"10.1002","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2512-9428","authenticated-orcid":false,"given":"Xiao","family":"Fu","sequence":"first","affiliation":[{"name":"Department of Hematology, Xiangya Hemophilia Diagnosis and Treatment Center, Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital Central South University  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Lei","sequence":"additional","affiliation":[{"name":"Powder Metallurgy Institute of Central South University  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shitao","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The 3rd Xiangya Hospital Central South University  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luling","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, The 3rd Xiangya Hospital Central South University  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Xiao","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"Department of Endocrinology, Xiangya Hospital Central South University  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gong","family":"Xiao","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"Department of Nephropathy, Xiangya Hospital Central South University  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,3]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.586073"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000510127"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/sdi.12745"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/08860221003606299"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3897\/folmed.63.e57713"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-019-1585-6"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10047-019-01110-w"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13637-9"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.memsci.2013.07.061"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm200591q"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pat.725"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2021.111953"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21062084"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2015.06.035"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.111301"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22052590"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2020.105451"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5001700"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.7b03927"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-018-6054-4"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2022.213012"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.111508"},{"key":"e_1_2_9_23_1","volume":"135","author":"Fu X.","year":"2022","journal-title":"Mater. 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