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To overcome these limitations, pH\u2010sensitive nanoparticles, Acetalated Dextran<jats:sub>6k<\/jats:sub>\u2010PEG<jats:sub>5k<\/jats:sub>\u2010PLA<jats:sub>2k<\/jats:sub>\u2010Taxol (ADPP\u2010PTX), non\u2010pH\u2010sensitive nanoparticles, and Propionic Anhydride modified Dextran<jats:sub>6k<\/jats:sub>\u2010PEG<jats:sub>5k<\/jats:sub>\u2010PLA<jats:sub>2k<\/jats:sub>\u2010Taxol (PDPP\u2010PTX) are developed for the delivery of Taxol. Compared with PDPP\u2010PTX, ADPP\u2010PTX shows higher sensitivity to acid response and greater anti\u2010proliferative effect on cancer cells. 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