{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T19:10:31Z","timestamp":1780945831923,"version":"3.54.1"},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T00:00:00Z","timestamp":1717632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100016355","name":"Xuzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["XWKYHT20230005"],"award-info":[{"award-number":["XWKYHT20230005"]}],"id":[{"id":"10.13039\/501100016355","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Traumatic brain injury (TBI) is the primary cause of child mortality and disability worldwide. It can result in severe complications that significantly impact children's quality of life, including post\u2010traumatic epilepsy (PTE). An increasing number of studies suggest that TBI\u2010induced oxidative stress and neuroinflammatory sequelae (especially, inflammation in the hippocampus region) may lead to the development of PTE. Due to the blood\u2013brain barrier (BBB), typical systemic pharmacological therapy for TBI cannot deliver berberine (BBR) to the targeted location in the early stages of the injury, although BBR has strong anti\u2010inflammatory properties. To break through this limitation, a microenvironment\u2010responsive gelatin methacrylate (GM) hydrogel to deliver poly(propylene sulfide)<jats:sub>60<\/jats:sub> (PPS<jats:sub>60<\/jats:sub>) and BBR (GM\/PB) is developed for regulating neuroinflammatory reactions and removing reactive oxygen species (ROS) in the brain trauma microenvironment through PPS<jats:sub>60<\/jats:sub>. In situ injection of the GM\/PB hydrogel efficiently bypasses the BBB and is administered directly to the surface of brain tissue. In post\u2010traumatic brain injury models, GM\/PB has the potential to mitigate oxidative stress and neuroinflammatory responses, facilitate functional recovery, and lessen seizing. These findings can lead to a new treatment for brain injuries, which minimizes complications and improves the quality of life.<\/jats:p>","DOI":"10.1002\/mabi.202400050","type":"journal-article","created":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T20:04:23Z","timestamp":1717013063000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Microenvironment\u2010Responsive Hydrogel Reduces Seizures After Traumatic Brain Injury in Juvenile Rats by Reducing Oxidative Stress and Hippocampal Inflammation"],"prefix":"10.1002","volume":"24","author":[{"given":"Zhengzhong","family":"Han","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Xuzhou Children's Hospital  No. 18 Sudi North Road, Quanshan District Xuzhou 221002 P. R. China"},{"name":"Clinical College Xuzhou Medical University No. 209 Tongshan Road Xuzhou 221002 P. R. 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