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Here, water\u2010insoluble beclometasone dipropionate (BDP) which is a potent anti\u2010inflammatory therapeutic agent but limited to topical applications so far, is encapsulated. Therefore, this work used an amphiphilic block copolymer self\u2010assembling into flexible polymeric filomicelles, which have recently proven to selectively target inflamed areas in patients with inflammatory bowel disease (IBD). The small diameter and flexibility of these filomicelles is considered beneficial for transepithelial passages, while their length minimizes the unspecific uptake into nontargeted cells. This work successfully establishes a protocol to load the water\u2010insoluble BDP into the core of the filomicelles, while maintaining the particle stability to prevent any premature drug release. The anti\u2010inflammatory efficacy of BDP\u2010loaded filomicelles is further investigated on lipopolysaccharide (LPS) stimulated human monocytes. In these ex vivo assays, the BDP\u2010loaded filomicelles significantly reduce TNF\u2010\u03b1, IL\u20106, IL\u20101\u00df, IL\u201012p70, IL\u201017a, and IL\u201023 release after 24 h. Additional time course study of drug\u2010loaded filomicelles and their comparison with a common water\u2010soluble and unspecific corticosteroid demonstrate\u00a0promising results with significant immune response suppression in stimulated monocytes after 2 and 6 h. These findings demonstrate the potential of polymeric filomicelles as a vehicle for potent water\u2010insoluble corticosteroids.<\/jats:p>","DOI":"10.1002\/mabi.202400179","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T13:01:36Z","timestamp":1716469296000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Anti\u2010Inflammatory Potential of Beclometasone\u2010Loaded Filomicelles on Activated Human Monocytes"],"prefix":"10.1002","volume":"24","author":[{"given":"Elena","family":"Gardey","sequence":"first","affiliation":[{"name":"Department of Internal Medicine IV (Gastroenterology Hepatology Infectious Diseases and Interdisciplinary Endoscopy) Jena University Hospital  Am Klinikum 1 07747 Jena Germany"},{"name":"Jena Center for Soft Matter (JCSM) Friedrich Schiller University Jena  Philosophenweg 7 07743 Jena 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