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Under the condition of high environmental humidity, solvent pair of chloroform and dimethylformamide is employed for post\u2010treatment onto pre\u2010formed PLA coating to induce the pore\u2010formation following the mechanism of BF and VIPS, respectively. A composite porous structure with both cellular\u2010like and bi\u2010continuous network morphologies is obtained. By tunning the experimental factors including the ratio of the solvent pair, environmental humidity, and temperature, morphological manipulation upon the pore morphology can be facilely achieved based on the control of mechanism transition between BF and VIPS. Paclitaxel is used as a model drug and loaded into the porous coating by the wicking effect of post\u2010immersion. Coatings with different morphological features show varying drug loading and release capacities. The 28\u2010day release test reveals dynamic release profiles between different coating samples, with the total release rate ranging from 35.70% to 79.96%. Optimal loading capacity of 19.28\u00a0\u00b5g cm<jats:sup>\u22122<\/jats:sup> and 28\u2010day release rate of 35.70% are achieved for the coating with composite BF\u2010VIPS structure. This research established a cost\u2010efficient strategy with high flexibility in the structural manipulation concerning the construction of drug\u2010eluting coating with the feature of manipulative drug delivery.<\/jats:p>","DOI":"10.1002\/mabi.202400273","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T18:14:12Z","timestamp":1721672052000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Study of Manipulative In Situ Pore\u2010Formation upon Polymeric Coating on Cylindrical Substrate for Sustained Drug Delivery"],"prefix":"10.1002","volume":"24","author":[{"given":"Hao","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Materials Science and Engineering School of Materials Science and Chemical Engineering Ningbo University  Ningbo 315211 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering School of Materials Science and Chemical Engineering Ningbo University  Ningbo 315211 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baozhang","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of General Surgery Ningbo Haishu People\u2019s Hospital  Ningbo 315000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Hepatopancreatobiliary Surgery The First Affiliated Hospital of Ningbo University  Ningbo 315010 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Hepatopancreatobiliary Surgery The First Affiliated Hospital of Ningbo University  Ningbo 315010 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2923-5554","authenticated-orcid":false,"given":"Wei","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering School of Materials Science and Chemical Engineering Ningbo University  Ningbo 315211 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,22]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26195905"},{"key":"e_1_2_8_2_1","first-page":"445","volume":"53","author":"Li Y. 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