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The membranes exhibit a homogeneous distribution of Zn\u2010phthalocyanine within the gelatin matrix, maintaining the structural integrity and photosensitizing properties of the phthalocyanine. Scanning electron microscopy revealed that the electrospun fibers possess diameters ranging results as 100\u2013300, 200\u2013700, and 300\u2013800\u00a0nm for Gel, ZnPc\/Gel 1, and ZnPc\/Gel 2, respectively. The addition of ZnPc does not decrease the hydrophilicity of the Gel membrane. The nanofibrous membranes showed good cytocompatibility, as indicated by the high viability of Vero cells exposed to membrane extracts. Furthermore, these composites supported cell adhesion and proliferation on their surfaces. The two Zn\u2010phthalocyanine\/gelatin nanofiber formulations exhibited significant antimicrobial activity toward <jats:italic>Escherichia Coli (E. Coli)<\/jats:italic> and <jats:italic>Staphylococcus Aureus (S. Aureus)<\/jats:italic> under visible light illumination, achieving reductions of 3.4 log<jats:sub>10<\/jats:sub> and 3.6 log<jats:sub>10<\/jats:sub> CFU\u00a0mL<jats:sup>\u22121<\/jats:sup> for <jats:italic>E. coli<\/jats:italic>, and 3.9 log<jats:sub>10<\/jats:sub> and 4.1 log<jats:sub>10<\/jats:sub> CFU\u00a0mL<jats:sup>\u22121<\/jats:sup> for <jats:italic>S. aureus<\/jats:italic>. These results demonstrate the potential of Zn\u2010phthalocyanine\/gelatin nanofibrous membranes as effective agents in antibacterial photodynamic therapy, providing a promising solution to control bacterial infections and antibiotic resistance.<\/jats:p>","DOI":"10.1002\/mabi.202400334","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T15:51:12Z","timestamp":1730217072000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Biocompatible Zn\u2010Phthalocyanine\/Gelatin Nanofiber Membrane for Antibacterial Therapy"],"prefix":"10.1002","volume":"25","author":[{"given":"Romina","family":"Clementi","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e1nica Facultad de Ciencias Qu\u00edmicas Universidad Nacional de C\u00f3rdoba Ciudad Universitaria  C\u00f3rdoba X5000HUA Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Angela","family":"Vargas","sequence":"additional","affiliation":[{"name":"Laboratorio de Microbiolog\u00eda Hospital Provincial Florencio Diaz  C\u00f3rdoba Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Cid","sequence":"additional","affiliation":[{"name":"Facultad Ciencias Exactas F\u00edsicas y Naturales Departamento de Qu\u00edmica Universidad Nacional de C\u00f3rdoba  Av. 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