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Despite its prevalence, treatment options remain limited. Current drugs, such as benznidazole, cause adverse effects possibly due to ineffective administration. In this context, nanoparticles offer a promising solution to target and control drug delivery by leading the effector site and minimizing side effects. This article focuses on zein\u2010casein\u2010based nanoparticles (Bioparticles, BP) coated with Eudragit L100\u201055 (BP:EU) for enteric delivery of benznidazole. BP:EU structures are synthesized to minimize premature drug release in the stomach, promoting release in the small intestine. Physical characterization confirmed the successful synthesis of BP:EU and their pH\u2010responsive trigger for drug release. These findings suggest that this material can be a promising approach for Chagas disease treatment, addressing challenges in benznidazole delivery that can lead to improved therapeutic responses.<\/jats:p>","DOI":"10.1002\/mabi.202400338","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T14:20:11Z","timestamp":1729261211000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Proteins\u2010Based Nanoparticles for Benznidazole Enteric Delivery"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6625-0374","authenticated-orcid":false,"given":"Victor A.","family":"Pilicita","sequence":"first","affiliation":[{"name":"Polymer Reaction Engineering Group INTEC (Universidad Nacional del Litoral\u2010CONICET)  G\u00fcemes 3450 Santa Fe 3000 Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3624-4501","authenticated-orcid":false,"given":"Ana S.","family":"Sonzogni","sequence":"additional","affiliation":[{"name":"Polymer Reaction Engineering Group INTEC (Universidad Nacional del Litoral\u2010CONICET)  G\u00fcemes 3450 Santa Fe 3000 Argentina"},{"name":"Facultad de Ingener\u00eda Qu\u00edmica (Universidad Nacional del Litoral) Santiago del Estero 2829  Santa Fe 3000 Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5302-2551","authenticated-orcid":false,"given":"Mariana","family":"Allasia","sequence":"additional","affiliation":[{"name":"Polymer Reaction Engineering Group INTEC (Universidad Nacional del Litoral\u2010CONICET)  G\u00fcemes 3450 Santa Fe 3000 Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florencia","family":"Borra","sequence":"additional","affiliation":[{"name":"Facultad de Ingener\u00eda Qu\u00edmica (Universidad Nacional del Litoral) Santiago del Estero 2829  Santa Fe 3000 Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3645-5317","authenticated-orcid":false,"given":"Roque J.","family":"Minari","sequence":"additional","affiliation":[{"name":"Polymer Reaction Engineering Group INTEC (Universidad Nacional del Litoral\u2010CONICET)  G\u00fcemes 3450 Santa Fe 3000 Argentina"},{"name":"Facultad de Ingener\u00eda Qu\u00edmica (Universidad Nacional del Litoral) Santiago del Estero 2829  Santa Fe 3000 Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7155-7170","authenticated-orcid":false,"given":"Ver\u00f3nica D.G.","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Polymer Reaction Engineering Group INTEC (Universidad Nacional del Litoral\u2010CONICET)  G\u00fcemes 3450 Santa Fe 3000 Argentina"},{"name":"Facultad de Bioqu\u00edmica y Ciencias Biol\u00f3gicas (Universidad Nacional del Litoral)  Ciudad Universitaria RN168 Santa Fe 3000 Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,18]]},"reference":[{"key":"e_1_2_8_1_1","unstructured":"WHO Global report on neglected tropical diseases 2024."},{"key":"e_1_2_8_2_1","unstructured":"Chagas disease (also known as American trypanosomiasis) (n.d.).https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/chagas\u2010disease\u2010(american\u2010trypanosomiasis)#:~:text=Chagas%20disease%2C%20also%20known%20as cruzi(accessed: April 2023)."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2019.00166"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60061-X"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(89)90108-2"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.7.1357"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-144-10-200605160-00006"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.04660-14"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2022.09.073"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222111654"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.15-0889"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2022.112678"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2023.123120"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2023.122754"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2014.06.036"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1120251"},{"key":"e_1_2_8_17_1","volume":"9","author":"Yan X.","year":"2022","journal-title":"Front. 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