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Until now, there is no method addressing AL and abdominal adhesions simultaneously. In this work, Bi\u2010PEG\u2013succinimidyl succinate (PEG\u2010NHS), amino\u2010gelatin (Agel) is combined with cefoperazone\u2010sulbactam (SCF) to prepare a multifunctional bioadhesive (SCF\/SEAgel) for the postoperative leakage and adhesion prevention. SCF\/SEAgel possesses a great sealing capability for tissue, with a bursting pressure of 54\u00a0kPa. The loaded SCF endows the systems with good antibacterial properties. The in vivo antiadhesion experiments show that SCF\/SEAgel possesses better anti\u2010adhesion properties than the commercially used sodium hyaluronate gel. In the cecum leakage model, the SCF\/SEAgel effectively seals the leakage with a survival rate of 100%, superior to commercial products (Sainaoning). Meanwhile, it significantly reduces tissue adhesion. Finally, the laparoscopic surgery with dogs shows that the SCF\/SEAgel can be injected through minimally invasive surgery, demonstrating its ease of use. Combined with its great biocompatibility, SCF\/SEAgel is very promising in intestinal surgery.<\/jats:p>","DOI":"10.1002\/mabi.202400372","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T08:33:50Z","timestamp":1731054830000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["In Situ Forming Injectable Gelatin\u2010Based Antibacterial Bioadhesives for Preventing Postoperative Leakage and Abdominal Adhesions"],"prefix":"10.1002","volume":"25","author":[{"given":"Shibo","family":"Hu","sequence":"first","affiliation":[{"name":"Department of General Surgery The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an Shaanxi 710061 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanglin","family":"Duan","sequence":"additional","affiliation":[{"name":"Institute of Medical Engineering Department of Biophysics School of Basic Medical Sciences Health Science 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