{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:58:39Z","timestamp":1785200319913,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T00:00:00Z","timestamp":1728864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The therapeutic efficacy of bortezomib (BTZ) is often limited due to low solubility, poor stability in vivo and nonspecific toxicity. Herein, a kind of catechol\u2010functionalized polyethylene glycol (mPEG\u2010CA) is first synthesized and then mPEG\u2010CA is readily used to conjugate with BTZ by the formation of dynamic boronate bonds to obtain PEGlyated BTZ prodrug (mPEG\u2010CA\u2010BTZ) with the ability of pH\u2010controlled disassembly and drug release. The structure and morphology, physicochemical characteristics, drug loading, and release as well as in vitro cytotoxicity of mPEG\u2010CA\u2010BTZ nanoparticles are investigated in detail. The results demonstrated that mPEG\u2010CA\u2010BTZ can not only self\u2010assemble into nanostructures with uniform size and stable dispersion in physiological pH condition (pH 7.4) but also respond to the tumor acid microenvironment and achieve pH\u2010controlled BTZ release by acid\u2010triggered cleavage of boronate bonds, decomposition of mPEG\u2010CA\u2010BTZ and thus disassembly of mPEG\u2010CA\u2010BTZ nanoparticles. mPEG\u2010CA\u2010BTZ nanoparticles are expected to have great potential as a promising nanoplatform for pharmaceutical formulations of BTZ to increase therapeutic efficacy and decrease side effects of BTZ. Considering the easily available and biocompatible excipients and simple preparation process, the strategy designed herein provides a facile and promising approach to synergistically integrate the function of PEGylation and pH\u2010sensitiveness into boronic acid\u2010containing small molecule pharmaceutical agents.<\/jats:p>","DOI":"10.1002\/mabi.202400383","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T17:58:21Z","timestamp":1728928701000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Facile Strategy for PEGylated Nanoprodrug of Bortezomib with Improved Stability, Enhanced Biocompatibility, pH\u2010Controlled Disassembly, and Release"],"prefix":"10.1002","volume":"25","author":[{"given":"Naikuan","family":"Fu","sequence":"first","affiliation":[{"name":"Department of Cardiology Chest Hospital Tianjin University  Tianjin 300222 China"},{"name":"Tianjin Key Laboratory of Cardiovascular Emergency and Critical Care Tianjin Municipal Science and Technology Bureau Chest Hospital Tianjin University  Tianjin 300222 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinan","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Polymer Science and Engineering Key Laboratory of Systems Bioengineering of the Ministry of Education School of Chemical Engineering and Technology Tianjin University  Tianjin 300350 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Chest Hospital Tianjin University  Tianjin 300222 China"},{"name":"Tianjin Key Laboratory of Cardiovascular Emergency and Critical Care Tianjin Municipal Science and Technology Bureau Chest Hospital Tianjin University  Tianjin 300222 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Chest Hospital Tianjin University  Tianjin 300222 China"},{"name":"Tianjin Key Laboratory of Cardiovascular Emergency and Critical Care Tianjin Municipal Science and Technology Bureau Chest Hospital Tianjin University  Tianjin 300222 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Chest Hospital Tianjin University  Tianjin 300222 China"},{"name":"Tianjin Key Laboratory of Cardiovascular Emergency and Critical Care Tianjin Municipal Science and Technology Bureau Chest Hospital Tianjin University  Tianjin 300222 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shicheng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Chest Hospital Tianjin University  Tianjin 300222 China"},{"name":"Tianjin Key Laboratory of Cardiovascular Emergency and Critical Care Tianjin Municipal Science and Technology Bureau Chest Hospital Tianjin University  Tianjin 300222 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7833-9715","authenticated-orcid":false,"given":"Jianhua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Polymer Science and Engineering Key Laboratory of Systems Bioengineering of the Ministry of Education School of Chemical Engineering and Technology Tianjin University  Tianjin 300350 China"},{"name":"Tianjin Key Laboratory of Membrane Science and Desalination Technology Tianjin University  Tianjin 300350 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,14]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1159"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201807941"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9CC01344J"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CC09956A"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871520620666200127141328"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612825666191106150018"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom12010051"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2020.119885"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/02652048.2021.1876175"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpolymj.2017.05.036"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2020.119173"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b06104"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.7b00258"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano8010015"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano5042054"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2020.12.008"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.07.022"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2019.06.033"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.111250"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9PY00217K"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9TB02174D"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2017.09.044"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7CS00521K"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b14319"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.giant.2023.100169"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2015.09.012"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfa.2023.132823"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/ma501258c"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmacrolett.5b00018"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201107144"}],"container-title":["Macromolecular Bioscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mabi.202400383","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T07:17:38Z","timestamp":1744183058000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mabi.202400383"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,14]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1002\/mabi.202400383"],"URL":"https:\/\/doi.org\/10.1002\/mabi.202400383","archive":["Portico"],"relation":{},"ISSN":["1616-5187","1616-5195"],"issn-type":[{"value":"1616-5187","type":"print"},{"value":"1616-5195","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,14]]},"assertion":[{"value":"2024-08-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2400383"}}