{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:40:40Z","timestamp":1792453240562,"version":"4.5.0"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pelvic organ prolapse (POP) affects many women, especially after menopause. POP occurs due to the descent of weakened supportive tissue. Current prolapse surgeries have high failure rates, due to disturbed wound healing caused by lower tissue regeneration and estrogen depletion. Absorbable poly\u20104\u2010hydroxybutyrate (P4HB) knit implants exhibited improved cell and tissue response leading to less complications from prolapse surgery. This study aims to enhance wound healing and improve surgical outcomes by using an electrospun (ES) P4HB scaffold (ES P4HB) that emulates natural tissue structure. Further 17\u03b2\u2010estradiol (E2)\u2010a prominent wound healing factor\u2010is incorporated into the scaffold (ES P4HB\u2010E2). Parous Dohne Merino sheep underwent posterior vaginal wall implantation of either P4HB (<jats:italic>n<\/jats:italic> = 6) or 17\u03b2\u2010estradiol relasing P4HB\u2010E2 (<jats:italic>n<\/jats:italic> = 6) scaffolds, or underwent native tissue repair (NTR) (<jats:italic>n<\/jats:italic> = 4). Vaginal explants were compared for short\u2010term host response in terms of gross necropsy, histomorphology, biomechanics, tissue\u2010integration, and degradation of P4HB at 3\u2010months post\u2010implantation. Both scaffolds show promising results with enhanced mechanical properties and increased macrophage infiltration compared to NTR, but without differences between scaffolds. Thus, it seems electrospun P4HB scaffolds already improve tissue integration and healing. Further long\u2010term studies are needed before these scaffolds can be used in clinical practice.<\/jats:p>","DOI":"10.1002\/mabi.202400412","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T21:48:52Z","timestamp":1740606532000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of Electrospun Poly\u20104\u2010Hydroxybutyrate as Biofunctional and Degradable Scaffold for Pelvic Organ Prolapse in a Vaginal Sheep Model"],"prefix":"10.1002","volume":"25","author":[{"given":"Krista L. 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