{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T11:41:17Z","timestamp":1765280477884,"version":"3.44.0"},"reference-count":81,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:00:00Z","timestamp":1747180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010801","name":"Xunta de Galicia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010801","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Low\u2010molecular\u2010weight peptide\u2010based hydrogels formed through self\u2010assembly have emerged as promising candidates for biomedical applications. While the self\u2010assembly process is known to affect the network morphology, its impact on mechanical properties and drug delivery remains poorly understood. In this work, it is explored how different gelation conditions influence the morphology, properties, and drug release profiles of dehydropeptide\u2010based gels. Additionally, it is presented and analyzed, for the first time, the crystal structure of a naphthalene <jats:italic>N<\/jats:italic>\u2010capped dehydropeptide (2\u2010Naph\u2010L\u2010Phe\u2010Z\u2010\u0394Phe\u2010OH), which reveals a maximum pore diameter of \u22484.08 \u00c5. By changing the preparation conditions, it is found that the stiffness of the hydrogels can vary by nearly three orders of magnitude. Employing spectroscopic and imaging techniques, the relationship between the gelation methods and the resulting mechanical properties is investigated. These findings suggest that the assembly structure, morphology, and non\u2010covalent interactions significantly influence the release profile of model drugs such as doxorubicin, methotrexate, and curcumin. These results provide valuable insights into how preparation conditions can impact the properties of peptide\u2010based hydrogels and their drug release profiles.<\/jats:p>","DOI":"10.1002\/mabi.202400449","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T10:33:26Z","timestamp":1747218806000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Self\u2010Assembly Pathway Influence on Dehydropeptide\u2010Based Gel Properties and Drug Release"],"prefix":"10.1002","volume":"25","author":[{"given":"S\u00e9rgio R. S.","family":"Veloso","sequence":"first","affiliation":[{"name":"Physics Centre of Minho and Porto Universities (CF\u2010UM\u2010UP) and LaPMET Associate Laboratory University of Minho  Campus de Gualtar Braga 4710\u2010057 Portugal"},{"name":"CINBIO Universidad de Vigo  Vigo 36310 Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4456-5655","authenticated-orcid":false,"given":"Thangavel","family":"Vijayakanth","sequence":"additional","affiliation":[{"name":"Shmunis School of Biomedicine and Cancer Research George S. Wise Faculty of Life Sciences Tel Aviv University  Tel Aviv 6997801 Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudha","family":"Shankar","sequence":"additional","affiliation":[{"name":"Shmunis School of Biomedicine and Cancer Research George S. Wise Faculty of Life Sciences Tel Aviv University  Tel Aviv 6997801 Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Fridman","sequence":"additional","affiliation":[{"name":"Schulich Faculty of Chemistry Technion\u2010Israel Institute of Technology  Haifa 32000 Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sigal","family":"Rencus\u2010Lazar","sequence":"additional","affiliation":[{"name":"Shmunis School of Biomedicine and Cancer Research George S. Wise Faculty of Life Sciences Tel Aviv University  Tel Aviv 6997801 Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loic","family":"Hilliou","sequence":"additional","affiliation":[{"name":"Department of Polymer Engineering Institute for Polymers and Composites (IPC) University of Minho  Guimar\u00e3es 4804\u2010533 Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro V.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Department of Polymer Engineering Institute for Polymers and Composites (IPC) University of Minho  Guimar\u00e3es 4804\u2010533 Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cacilda","family":"Moura","sequence":"additional","affiliation":[{"name":"Physics Centre of Minho and Porto Universities (CF\u2010UM\u2010UP) and LaPMET Associate Laboratory University of Minho  Campus de Gualtar Braga 4710\u2010057 Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula M. T.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Chemistry Centre of the University of Minho Campus de Gualtar  Braga 4710\u2010057 Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel A.","family":"Correa\u2010Duarte","sequence":"additional","affiliation":[{"name":"CINBIO Universidad de Vigo  Vigo 36310 Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabete M. S.","family":"Castanheira","sequence":"additional","affiliation":[{"name":"Physics Centre of Minho and Porto Universities (CF\u2010UM\u2010UP) and LaPMET Associate Laboratory University of Minho  Campus de Gualtar Braga 4710\u2010057 Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5764-1720","authenticated-orcid":false,"given":"Ehud","family":"Gazit","sequence":"additional","affiliation":[{"name":"Shmunis School of Biomedicine and Cancer Research George S. Wise Faculty of Life Sciences Tel Aviv University  Tel Aviv 6997801 Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,14]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.2c05601"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24010186"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41570-020-0215-y"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.0c01483"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/la301371q"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4SM02532F"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cocis.2022.101645"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39648-2"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3SM00339F"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2TC05320A"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2021.111869"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/b921863g"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202211277"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42004-019-0170-z"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2SM00926A"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1NR08158F"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels9120953"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph15091048"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2SM00663D"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5SM00843C"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-019-0111-6"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.cgd.7b00709"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20235850"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5SM00808E"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.2c01394"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24213855"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/bip.22435"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-023-01765-0"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0SM01217C"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4RA05808A"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-021-00793-y"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.2c00356"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/la9011058"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22052528"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.200601774"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels4020032"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/la500589f"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4CS00066H"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4MH00223G"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2020.00217"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2020.09.032"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201705604"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnnfm.2014.09.008"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/psc.3305"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4SM02256D"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadva.2023.100086"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3TA06663K"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2015.27"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3AN00124E"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar400006z"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1042\/ETLS20200256"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2615"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5CS00889A"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodhyd.2022.107751"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201902709"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1021\/la500679b"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1021\/la400994v"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/bip.22034"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11224-019-01387-w"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep31167"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrs.4290"},{"key":"e_1_2_7_62_1","first-page":"1","volume":"11","author":"Veloso S. R. S.","year":"2021","journal-title":"Nanomaterials"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp500650p"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2007.06.004"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja0356176"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8RA04491K"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4CS00247D"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm301007r"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1039\/B916738B"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.3c01304"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels3030029"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep08764"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202012470"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijms.2017.06.011"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.2c02193"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.progpolymsci.2011.02.002"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-3659(87)90035-6"},{"key":"e_1_2_7_78_1","first-page":"217","volume":"67","author":"Dash S.","year":"2010","journal-title":"Acta Pol. Pharm. \u2013 Drug Res."},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels7020052"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0TB01157F"},{"key":"e_1_2_7_81_1","first-page":"1","volume":"8","author":"Chan K. H.","year":"2018","journal-title":"Sci. Rep."}],"container-title":["Macromolecular Bioscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mabi.202400449","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T10:01:19Z","timestamp":1757930479000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mabi.202400449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,14]]},"references-count":81,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/mabi.202400449"],"URL":"https:\/\/doi.org\/10.1002\/mabi.202400449","archive":["Portico"],"relation":{},"ISSN":["1616-5187","1616-5195"],"issn-type":[{"type":"print","value":"1616-5187"},{"type":"electronic","value":"1616-5195"}],"subject":[],"published":{"date-parts":[[2025,5,14]]},"assertion":[{"value":"2024-10-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"70003"}}