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However, the concomitant adverse effect of delayed diarrhea has hindered its clinical use. CPT\u201011 combined with Thalidomide (THA) therapy is considered a palliative strategy. To optimize the synergistic treatment of CPT\u201011 and THA, co\u2010loaded liposomes are constructed using cholesterol, lecithin, and 1, 2\u2010Distearoyl\u2010sn\u2010glycero\u20103\u2010phosphoethanolamine\u2010Poly(ethylene glycol) (DSPE\u2010PEG) as the \u201cimmune and gut microbiota regulator.\u201d The co\u2010loaded liposomes, which possess good stability, are prepared by the solvent injection method. After the treatment with the co\u2010loaded liposomes, tumor growth in CRC\u2010bearing mice is significantly inhibited. In particular, the co\u2010loaded liposomes demonstrate favorable diarrhea\u2010relieving effects through the modulation of inflammatory cytokines and gut microbiota. These findings suggest that the co\u2010loaded liposomes have great potential as a combined drug\u2010delivery platform for CRC therapy.<\/jats:p>","DOI":"10.1002\/mabi.202400478","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T09:45:24Z","timestamp":1734687924000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Nanoscale Liposomes Co\u2010Loaded with Irinotecan Hydrochloride and Thalidomide for Colorectal Cancer Synergistic Therapy"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5414-9300","authenticated-orcid":false,"given":"Xuanrong","family":"Sun","sequence":"first","affiliation":[{"name":"Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals &amp; College of Pharmaceutical Science Zhejiang University of Technology  Hangzhou 310014 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubei","family":"Gong","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals &amp; College of Pharmaceutical Science Zhejiang University of Technology  Hangzhou 310014 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Xie","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals &amp; College of Pharmaceutical Science Zhejiang University of Technology  Hangzhou 310014 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixi","family":"Fu","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals &amp; College of Pharmaceutical Science Zhejiang University of Technology  Hangzhou 310014 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongze","family":"Lu","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals &amp; College of Pharmaceutical Science Zhejiang University of Technology  Hangzhou 310014 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wei","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals &amp; College of Pharmaceutical Science Zhejiang University of Technology  Hangzhou 310014 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Cai","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals &amp; College of Pharmaceutical Science Zhejiang University of Technology  Hangzhou 310014 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenlong","family":"Yao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences and Chemical Biology Center Peking University  Xue Yuan Road No. 38 Beijing 100191 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5849-7657","authenticated-orcid":false,"given":"Jie","family":"Shen","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals &amp; College of Pharmaceutical Science Zhejiang University of Technology  Hangzhou 310014 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,20]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.348226.120"},{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i29.9862"},{"key":"e_1_2_8_1_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2024.109689"},{"key":"e_1_2_8_2_1","first-page":"5077","volume":"49","author":"Hsiang Y. 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