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Moreover, the need for urinary diversion after radical cystectomy significantly impacts quality of life, leading to reluctance toward surgery. Therefore, developing tumor\u2010targeted therapies and alternative treatment strategies for MIBC is of great clinical significance. In this study, the IR780 iodide multifunctional dye is conjugated to alginate polysaccharide and developed a novel cisplatin\u2010loaded nanoparticle. Then, the tumor targeting and antitumor effects of the nanoparticles are evaluated in vitro and in vivo. The results show that the nanoparticles have sufficient drug loading, enhanced tumor targeting, and good photothermal effect. Furthermore, they shows potential for tumor imaging and diagnostic applications in a mouse model of MIBC. This study proposes a potentially effective treatment for MIBC by combining near\u2010infrared\u00a0localized phototherapy with systemic chemotherapy to eliminate malignant tissue.<\/jats:p>","DOI":"10.1002\/mabi.202400575","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T09:51:18Z","timestamp":1743501078000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Drug\u2010Loaded Mitochondrial Targeted Nanoparticles for Tumor Imaging and PDT\/PTT Combined Chemotherapy in Muscle\u2010Invasive Bladder Cancer"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0687-058X","authenticated-orcid":false,"given":"Yuandi","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Urology The Third Affiliated Hospital of Chongqing Medical University  Chongqing 401120 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Urology The Third Affiliated Hospital of Chongqing Medical University  Chongqing 401120 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heping","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Urology The Third Affiliated Hospital of Chongqing Medical University  Chongqing 401120 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongxing","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Urology The Third Affiliated Hospital of Chongqing Medical University  Chongqing 401120 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology The Third Affiliated Hospital of Chongqing Medical University  Chongqing 401120 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benhuang","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Urology The Third Affiliated Hospital of Chongqing Medical University  Chongqing 401120 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Urology The Third Affiliated Hospital of Chongqing Medical University  Chongqing 401120 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Urology The Third Affiliated Hospital of Chongqing Medical University  Chongqing 401120 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weibing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Urology The Third Affiliated Hospital of Chongqing Medical University  Chongqing 401120 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunmeng","family":"Shi","sequence":"additional","affiliation":[{"name":"Institute of Rocket Force Medicine State Key Laboratory of Trauma and Chemical Poisoning Army Medical University  Chongqing 400038 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4325-7721","authenticated-orcid":false,"given":"Yi","family":"Zhi","sequence":"additional","affiliation":[{"name":"Department of Urology The Third Affiliated Hospital of Chongqing Medical University  Chongqing 401120 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,31]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S387289"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2024.04.004"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2020.05.042"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.22"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2020.03.055"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1171-1213"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1166\/jbn.2019.2670"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c07040"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202102587"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15020330"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22136658"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2022.103795"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2023.100938"},{"key":"e_1_2_8_15_1","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.879828","volume":"12","author":"Lu Y.","year":"2022","journal-title":"Front. 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