{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T20:58:56Z","timestamp":1771275536651,"version":"3.50.1"},"reference-count":208,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2411300"],"award-info":[{"award-number":["2023YFC2411300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32471392"],"award-info":[{"award-number":["32471392"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2682023ZTPY056"],"award-info":[{"award-number":["2682023ZTPY056"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2682024ZTPY003"],"award-info":[{"award-number":["2682024ZTPY003"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dermatological diseases represent one of the most prevalent health concerns globally, with associated care and treatment costs having consistently increased over the past decade. Current therapeutic modalities, including topical medications, oral pharmaceuticals, and physical therapies, frequently face challenges such as inadequate drug absorption and substantial adverse effects. Microneedles, recognized as minimally invasive drug delivery systems, effectively penetrate the cutaneous barrier to enhance drug permeability and therapeutic efficacy. Polyphenols\u2014abundant in botanical and marine sources\u2014demonstrate diverse pharmacological properties encompassing anti\u2010inflammatory and antioxidant activities. The integration of polyphenols with microneedle technology has emerged as a promising therapeutic strategy for dermatological conditions, demonstrating significant clinical potential. This review examines the multifunctional capabilities of polyphenol\u2010incorporated microneedles and elucidates their mechanisms of action in managing dermatological disorders. Furthermore, it synthesizes recent progress in polyphenol\u2010based microneedle applications for various cutaneous pathologies, including acne vulgaris, psoriasis, and atopic dermatitis. Finally, current challenges is discussed and proposed future research directions for optimizing polyphenol microneedle systems in dermatological therapeutics.<\/jats:p>","DOI":"10.1002\/mabi.202400607","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T05:23:39Z","timestamp":1741757019000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Polyphenol Microneedles for Dermatological Therapy"],"prefix":"10.1002","volume":"25","author":[{"given":"Chubao","family":"Liu","sequence":"first","affiliation":[{"name":"Institute of Biomedical Engineering, College of Medicine Southwest Jiaotong University  Chengdu Sichuan 610031 China"},{"name":"Key Lab of Advanced Technologies of Materials Ministry of Education School of Materials Science and Engineering Southwest Jiaotong University  Chengdu Sichuan 610031 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhui","family":"Ran","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering, College of Medicine Southwest Jiaotong University  Chengdu Sichuan 610031 China"},{"name":"Key Lab of Advanced Technologies of Materials Ministry of Education School of Materials Science and Engineering Southwest Jiaotong University  Chengdu Sichuan 610031 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiping","family":"Xie","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering, College of Medicine Southwest Jiaotong University  Chengdu Sichuan 610031 China"},{"name":"Key Lab of Advanced Technologies of Materials Ministry of Education School of Materials Science and Engineering Southwest Jiaotong University  Chengdu Sichuan 610031 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiong","family":"Lu","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering, College of Medicine Southwest Jiaotong University  Chengdu Sichuan 610031 China"},{"name":"Key Lab of Advanced Technologies of Materials Ministry of Education School of Materials Science and Engineering Southwest Jiaotong University  Chengdu Sichuan 610031 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry School and Hospital of Stomatology, Cheeloo College of Medicine Shandong University &amp; Shandong Key Laboratory of Oral Tissue Regeneration &amp; Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration &amp; Shandong Provincial Clinical Research Center for Oral Diseases  Jinan Shandong 250012 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6916-675X","authenticated-orcid":false,"given":"Chaoming","family":"Xie","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering, College of Medicine Southwest Jiaotong University  Chengdu Sichuan 610031 China"},{"name":"Key Lab of Advanced Technologies of Materials Ministry of Education School of Materials Science and Engineering Southwest Jiaotong University  Chengdu Sichuan 610031 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,28]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mpsur.2010.07.011"},{"key":"e_1_2_7_2_1","volume-title":"\u201cThe structure and function of skin\u201d","author":"Montagna W.","year":"1974"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222111676"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22063035"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abo0693"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.274"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eng.2023.05.009"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40204-021-00154-7"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2014.06.002"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.02.043"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21081063"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-020-03233-6"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.08.034"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200203010-00005"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1124\/pharmrev.123.000549"},{"key":"e_1_2_7_16_1","first-page":"533","volume":"14","author":"Parvatala A.","year":"2024","journal-title":"Int. J. Med. Public Health"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2020.101877"},{"key":"e_1_2_7_18_1","volume":"10","author":"Al\u2010Wahaab Z. M. A.","year":"2024","journal-title":"Heliyon"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.178903"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20142872"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gerinurse.2021.11.022"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.09.074"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.5114\/reum.2018.80718"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2014.927816"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2016.04.005"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abd.2021.03.001"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-009-0716-x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/app11083626"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S87987"},{"key":"e_1_2_7_30_1","first-page":"22","volume":"4","author":"Del Rosso J. Q.","year":"2011","journal-title":"J. Clin. Aesthet. Dermatol."},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.2c08016"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-020-00409-4"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13346-021-00909-6"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.112633"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2017.02.011"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2003.10.023"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2020.12.004"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2020.101923"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-021-00910-7"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202404538"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202300575"},{"key":"e_1_2_7_42_1","volume":"5","author":"Chen Z.","year":"2024","journal-title":"Innovation"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.34133\/2020\/3672120"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym15204059"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2020.119673"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202002129"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adf0854"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2024.104016"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.3c08368"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smaim.2024.05.002"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smaim.2022.08.004"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smaim.2024.02.001"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1080\/10942912.2016.1220393"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2621.2009.02077.x"},{"key":"e_1_2_7_55_1","author":"Xiao F.","year":"2023","journal-title":"Mater. Res. Express"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-398456-2.00020-7"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10071044"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.153425"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2024.07.228"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/mame.201900669"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1GC04828G"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2019.05.184"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2018.1545767"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/79.5.727"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8FO01997E"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.4314\/ajtcam.v11i3.2"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/81.1.215S"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2018.00087"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10111618"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/504253"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2012.06510.x"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.3109\/10715769509145649"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2019.1637006"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.3390\/app11188276"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfda.2016.05.003"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1177\/08853282211058099"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-08-045316-3.00008-9"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1381-5148(02)00091-3"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1159\/000355523"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43094-020-00161-8"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1699"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2024.124690"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods13152441"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b13-00459"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1021\/np9801559"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.4196\/kjpp.2008.12.6.343"},{"key":"e_1_2_7_87_1","first-page":"41","volume":"25","author":"Alexandru V.","year":"2015","journal-title":"Studia Univ.\u201c VG\u201d Arad. SSV"},{"key":"e_1_2_7_88_1","volume":"14","author":"Oliveira M. M.","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"e_1_2_7_89_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2012.01118.x"},{"key":"e_1_2_7_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymdegradstab.2021.109603"},{"key":"e_1_2_7_91_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2TB01056A"},{"key":"e_1_2_7_92_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b10818"},{"key":"e_1_2_7_93_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088062"},{"key":"e_1_2_7_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2015.05.016"},{"key":"e_1_2_7_95_1","doi-asserted-by":"publisher","DOI":"10.22271\/journalofsport.2021.v6.i1e.2236"},{"key":"e_1_2_7_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9120(96)00155-5"},{"key":"e_1_2_7_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(99)00410-5"},{"key":"e_1_2_7_98_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26010229"},{"key":"e_1_2_7_99_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40104-022-00822-z"},{"key":"e_1_2_7_100_1","doi-asserted-by":"publisher","DOI":"10.1002\/cnr2.1353"},{"key":"e_1_2_7_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2021.05.001"},{"key":"e_1_2_7_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2023.105257"},{"key":"e_1_2_7_103_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3BM00132F"},{"key":"e_1_2_7_104_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9932218"},{"key":"e_1_2_7_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2018.01.054"},{"key":"e_1_2_7_106_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40005-021-00512-4"},{"key":"e_1_2_7_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smaim.2024.08.004"},{"key":"e_1_2_7_108_1","doi-asserted-by":"publisher","DOI":"10.3762\/bjnano.12.77"},{"key":"e_1_2_7_109_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12060569"},{"key":"e_1_2_7_110_1","doi-asserted-by":"publisher","DOI":"10.34133\/research.0420"},{"key":"e_1_2_7_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2021.120455"},{"key":"e_1_2_7_112_1","doi-asserted-by":"publisher","DOI":"10.1201\/9780367855147-10"},{"key":"e_1_2_7_113_1","doi-asserted-by":"publisher","DOI":"10.3109\/1061186X.2012.741136"},{"key":"e_1_2_7_114_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.119.258707"},{"key":"e_1_2_7_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xphs.2015.12.008"},{"key":"e_1_2_7_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.05.013"},{"key":"e_1_2_7_117_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-016-1885-5"},{"key":"e_1_2_7_118_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym13040520"},{"key":"e_1_2_7_119_1","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2005.845240"},{"key":"e_1_2_7_120_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0b013e318225dbe9"},{"key":"e_1_2_7_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2017.03.383"},{"key":"e_1_2_7_122_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels10040264"},{"key":"e_1_2_7_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2006.10.017"},{"key":"e_1_2_7_124_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10544-019-0462-1"},{"key":"e_1_2_7_125_1","doi-asserted-by":"publisher","DOI":"10.3390\/mi11080710"},{"key":"e_1_2_7_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mattod.2022.12.007"},{"key":"e_1_2_7_127_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202004873"},{"key":"e_1_2_7_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.12.048"},{"key":"e_1_2_7_129_1","volume":"2022","author":"Wang Y.","year":"2022","journal-title":"Research"},{"key":"e_1_2_7_130_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12040366"},{"key":"e_1_2_7_131_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202001691"},{"key":"e_1_2_7_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.05.045"},{"key":"e_1_2_7_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2021.120749"},{"key":"e_1_2_7_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2024.11.001"},{"key":"e_1_2_7_135_1","doi-asserted-by":"publisher","DOI":"10.1002\/sstr.202400121"},{"key":"e_1_2_7_136_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202311535"},{"key":"e_1_2_7_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.11.046"},{"key":"e_1_2_7_138_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3BM00182B"},{"key":"e_1_2_7_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.05.032"},{"key":"e_1_2_7_140_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13346-020-00735-2"},{"key":"e_1_2_7_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2024.112639"},{"key":"e_1_2_7_142_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14071404"},{"key":"e_1_2_7_143_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c01790"},{"key":"e_1_2_7_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2023.109457"},{"key":"e_1_2_7_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.07.063"},{"key":"e_1_2_7_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2018.06.001"},{"key":"e_1_2_7_147_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.0c00150"},{"key":"e_1_2_7_148_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0MH01317J"},{"key":"e_1_2_7_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.03.018"},{"key":"e_1_2_7_150_1","doi-asserted-by":"publisher","DOI":"10.1021\/accountsmr.3c00055"},{"key":"e_1_2_7_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2021.03.056"},{"key":"e_1_2_7_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seppur.2023.125861"},{"key":"e_1_2_7_153_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c03050"},{"key":"e_1_2_7_154_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c08979"},{"key":"e_1_2_7_155_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29040865"},{"key":"e_1_2_7_156_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27227832"},{"key":"e_1_2_7_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2017.11.048"},{"key":"e_1_2_7_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2021.149719"},{"key":"e_1_2_7_159_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13010273"},{"key":"e_1_2_7_160_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-022-08156-9"},{"key":"e_1_2_7_161_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2015.2544"},{"key":"e_1_2_7_162_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0b013e31816778f9"},{"key":"e_1_2_7_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2020.102284"},{"key":"e_1_2_7_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2014.06.010"},{"key":"e_1_2_7_165_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.12.007"},{"key":"e_1_2_7_166_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c08979"},{"key":"e_1_2_7_167_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-007-9286-4"},{"key":"e_1_2_7_168_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c07091"},{"key":"e_1_2_7_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.126013"},{"key":"e_1_2_7_170_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700340"},{"key":"e_1_2_7_171_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms251810152"},{"key":"e_1_2_7_172_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.29"},{"key":"e_1_2_7_173_1","first-page":"475","volume":"100","author":"Og\u00e9 L. K.","year":"2019","journal-title":"Am. Fam. Physician"},{"key":"e_1_2_7_174_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abh1478"},{"key":"e_1_2_7_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2004.03.005"},{"key":"e_1_2_7_176_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.292"},{"key":"e_1_2_7_177_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-015-0236-1"},{"key":"e_1_2_7_178_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2011.00583.x"},{"key":"e_1_2_7_179_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12827"},{"key":"e_1_2_7_180_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20061475"},{"key":"e_1_2_7_181_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032713-120225"},{"key":"e_1_2_7_182_1","doi-asserted-by":"crossref","unstructured":"J.De Korte F. M.Mombers J. D.Bos M. A.Sprangers inJournal of Investigative Dermatology Symposium Proceedings Elsevier 2004 p.9\/140.","DOI":"10.1046\/j.1087-0024.2003.09110.x"},{"key":"e_1_2_7_183_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.12.054"},{"key":"e_1_2_7_184_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.1067051"},{"key":"e_1_2_7_185_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241713313"},{"key":"e_1_2_7_186_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/2416837"},{"key":"e_1_2_7_187_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-009-1001-3"},{"key":"e_1_2_7_188_1","doi-asserted-by":"publisher","DOI":"10.1002\/adtp.202300233"},{"key":"e_1_2_7_189_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abe2888"},{"key":"e_1_2_7_190_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12495"},{"key":"e_1_2_7_191_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70051-5"},{"key":"e_1_2_7_192_1","first-page":"35","volume":"86","author":"Berke R.","year":"2012","journal-title":"Am. Fam. Physician"},{"key":"e_1_2_7_193_1","doi-asserted-by":"publisher","DOI":"10.20344\/amp.11963"},{"key":"e_1_2_7_194_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms15058293"},{"key":"e_1_2_7_195_1","first-page":"590","volume":"101","author":"Frazier W.","year":"2020","journal-title":"Am. Fam. Physician"},{"key":"e_1_2_7_196_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007990903512156"},{"key":"e_1_2_7_197_1","doi-asserted-by":"publisher","DOI":"10.3390\/cosmetics11030101"},{"key":"e_1_2_7_198_1","first-page":"20","volume":"3","author":"Davis E. C.","year":"2010","journal-title":"J. Clin. Aesthet. Dermatol."},{"key":"e_1_2_7_199_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2021.06.007"},{"key":"e_1_2_7_200_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12986"},{"key":"e_1_2_7_201_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12235"},{"key":"e_1_2_7_202_1","doi-asserted-by":"publisher","DOI":"10.1177\/20595131211029206"},{"key":"e_1_2_7_203_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(98)00245-7"},{"key":"e_1_2_7_204_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-44766-3_3"},{"key":"e_1_2_7_205_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2012.04.004"},{"key":"e_1_2_7_206_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-405205-5.00026-X"},{"key":"e_1_2_7_207_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c07829"},{"key":"e_1_2_7_208_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym14204436"}],"container-title":["Macromolecular Bioscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mabi.202400607","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T17:01:57Z","timestamp":1750093317000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mabi.202400607"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,28]]},"references-count":208,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1002\/mabi.202400607"],"URL":"https:\/\/doi.org\/10.1002\/mabi.202400607","archive":["Portico"],"relation":{},"ISSN":["1616-5187","1616-5195"],"issn-type":[{"value":"1616-5187","type":"print"},{"value":"1616-5195","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,28]]},"assertion":[{"value":"2024-12-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2400607"}}