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Therefore, inhibiting excessive inflammation and promoting tissue repair are important for myocardial repair. Based on this, natural polymeric Silk Fibroin Methacryloyl microneedles loaded with Tc peptide drugs (SilMA MNs) were fabricated for the MI therapy by photocuring and micro\u2010molding techniques, which facilitate the protection of Tc peptides that can be rapidly degraded in physiological environments. SilMA MNs containing Tc could promote proliferation and spreading of AC16 and H9C2 cardiomyocytes, alleviate excessive inflammation of macrophages under LPS induction, and further migration and angiogenesis of HUVECs endothelial cell, showing the potential for MI treatment in clinical applications.<\/jats:p>","DOI":"10.1002\/mabi.202400614","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T17:54:30Z","timestamp":1754070870000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Peptide\u2010Laden Silk Fibroin Microneedles Modulate Inflammation and Promote Myocardial Repair In Vitro"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0655-3805","authenticated-orcid":false,"given":"Xueting","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cardiology The First Affiliated Hospital of Soochow University  Suzhou 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