{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T03:52:56Z","timestamp":1786679576141,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T00:00:00Z","timestamp":1744070400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromolecular Bioscience"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The application of photosensitizers (PSs) in antibacterial photodynamic therapy is significantly restricted by the aggregation\u2010caused quenching (ACQ) effect of PSs. Porous organic polymers (POPs) serve as efficient molecular carriers benefiting from its microporous structure and functional groups. Here, an ester\u2010linked POP (e\u2010POP) bearing benzophenone groups is prepared from 3,3\u2032,4,4\u2032\u2010benzophenonetetracarboxylic dianhydride (BPTCD) and phloroglucinol (PG). It exhibits a specific surface area of 14.837\u00a0m<jats:sup>2<\/jats:sup>\u00a0g<jats:sup>\u22121<\/jats:sup> and a pore size of 3.421\u00a0nm, enabling it to adsorb methylene blue (MB) molecules (MB@e\u2010POP). The negatively\u2010charged e\u2010POP (containing 4.671\u00a0mmol\u00a0g<jats:sup>\u22121<\/jats:sup> carboxyl groups) can attract and stably load the positively\u2010charged MB. The adsorption of MB on e\u2010POP conforms to the Langmuir isotherm and pseudo\u2010second\u2010order kinetic models, with a maximum capacity of 400.5\u00a0mg\u00a0g<jats:sup>\u22121<\/jats:sup>. Compared with MB and e\u2010POP alone, MB@e\u2010POP demonstrates a remarkable increase in the antibacterial rate, 42.42% and 19.63% higher for Escherichia coli (<jats:italic>E. coli<\/jats:italic>) and 44.62% and 25.54% higher for Staphylococcus aureus (<jats:italic>S. aureus<\/jats:italic>), respectively. The high antibacterial efficacy is ascribed to the distribution of MB within mesopores of e\u2010POP and the synergistic effect of MB with e\u2010POP in reactive oxygen species (ROS) generation. Thus, it achieves 99.99% antibacterial rate under 10\u00a0min light irradiation and maintains efficient sterilization even after 20 cycles of use.<\/jats:p>","DOI":"10.1002\/mabi.202500087","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T19:05:48Z","timestamp":1744139148000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Highly\u2010Efficient and Synergistic Antibacterial Photodynamic Therapy Effect of Ester\u2010Linked Porous Organic Polymer and Methylene Blue"],"prefix":"10.1002","author":[{"given":"Jianxun","family":"Liu","sequence":"first","affiliation":[{"name":"College of Chemistry and Chemical Engineering, National Engineering Research Center for Dyeing and Finishing of Textiles Donghua University  Shanghai 201620 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering, National Engineering Research Center for Dyeing and Finishing of Textiles Donghua University  Shanghai 201620 China"},{"name":"College of Chemistry and Chemical Engineering Donghua University  Shanghai 201620 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linping","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering Donghua University  Shanghai 201620 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhong","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering Donghua University  Shanghai 201620 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering, National Engineering Research Center for Dyeing and Finishing of Textiles Donghua University  Shanghai 201620 China"},{"name":"College of Chemistry and Chemical Engineering Donghua University  Shanghai 201620 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiping","family":"Mao","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering, National Engineering Research Center for Dyeing and Finishing of Textiles Donghua University  Shanghai 201620 China"},{"name":"College of Chemistry and Chemical Engineering Donghua University  Shanghai 201620 China"},{"name":"National Innovation Center of Advanced Dyeing &amp; Finishing Technology  Tai'an Shandong Province 271000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1801-5097","authenticated-orcid":false,"given":"Bolin","family":"Ji","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering, National Engineering Research Center for Dyeing and Finishing of Textiles Donghua University  Shanghai 201620 China"},{"name":"College of Chemistry and Chemical Engineering Donghua University  Shanghai 201620 China"},{"name":"National Innovation Center of Advanced Dyeing &amp; Finishing Technology  Tai'an Shandong Province 271000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,8]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1126\/science.aam8335","volume":"357","author":"Metcalf C. 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Technol."},{"key":"e_1_2_9_17_1","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1080\/02652048.2016.1216187","volume":"33","author":"Ghayempour S.","year":"2016","journal-title":"J. Microencapsulation"},{"key":"e_1_2_9_18_1","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14429","volume":"8","author":"Yang Q.","year":"2017","journal-title":"Nat. Commun."},{"key":"e_1_2_9_19_1","doi-asserted-by":"crossref","first-page":"7202","DOI":"10.3390\/ijms22137202","volume":"22","author":"Bruna T.","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"e_1_2_9_20_1","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aar5931","volume":"4","author":"Si Y.","year":"2018","journal-title":"Sci. Adv."},{"key":"e_1_2_9_21_1","doi-asserted-by":"crossref","DOI":"10.1021\/acsami.9b07992","volume":"11","author":"Hu L.","year":"2019","journal-title":"ACS Appl. Mater. 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Photobiol."},{"key":"e_1_2_9_31_1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1039\/D2RA06484G","volume":"13","author":"Zhang H.","year":"2023","journal-title":"RSC Adv."},{"key":"e_1_2_9_32_1","doi-asserted-by":"crossref","first-page":"5089","DOI":"10.1039\/C9TB01069F","volume":"7","author":"Yao T.","year":"2019","journal-title":"J. Mater. Chem. B"},{"key":"e_1_2_9_33_1","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/php.13680","volume":"99","author":"Lv Y.","year":"2023","journal-title":"Photochem. Photobiol."},{"key":"e_1_2_9_34_1","doi-asserted-by":"crossref","DOI":"10.1002\/smll.201602580","volume":"13","author":"Fang S.","year":"2017","journal-title":"Small"},{"key":"e_1_2_9_35_1","doi-asserted-by":"crossref","first-page":"6458","DOI":"10.1021\/acsapm.4c00716","volume":"6","author":"Zhang K.","year":"2024","journal-title":"ACS Appl. Polym. 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