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Traditional therapies typically manage infection and inflammation but seldom restore lost tissue. In this way, injectable hydrogels have emerged as versatile biomaterials that adapt to the complex anatomy of the dentin\u2010pulp complex and periodontal lesions. Generally speaking, by incorporating antimicrobial, anti\u2010inflammatory, and pro\u2010regenerative cues, these hydrogels support localized disinfection, promote angiogenesis, and foster tissue regeneration. More specifically, recent advances in functionalizing hydrogels with growth factors, bioactive compounds, and dentin matrix components have effectively modulated inflammatory responses, stimulated host cell activity, and facilitated the formation of hard and soft tissue for regenerative endodontic therapies. In periodontology, engineered hydrogels have demonstrated their ability to deliver osteogenic, antimicrobial, and immunomodulatory agents while also enabling the encapsulation of stem cells or extracellular vesicles, thereby enhancing cellular activity and supporting the regeneration of alveolar bone and soft tissue. This review summarizes recent advancements in injectable hydrogels for regenerating the dentin\u2010pulp complex and periodontal tissues, discussing their design principles, performance, and future directions. Although not exhaustive, it provides a comprehensive overview to inspire further research and innovation, encouraging the development of novel, easy\u2010to\u2010apply, and highly biocompatible multifunctional hydrogels for regenerative dental medicine.<\/jats:p>","DOI":"10.1002\/mabi.202500096","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:09:27Z","timestamp":1751501367000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Recent Advances in Injectable Hydrogel Biotherapeutics for Regenerative Dental Medicine"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4125-8441","authenticated-orcid":false,"given":"Renan","family":"Dal\u2010Fabbro","sequence":"first","affiliation":[{"name":"Department of Cariology Restorative Sciences and Endodontics School of Dentistry University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8328-1818","authenticated-orcid":false,"given":"Arwa","family":"Daghrery","sequence":"additional","affiliation":[{"name":"Department of Restorative Dental Sciences School of Dentistry Jazan University  Jazan Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3189-1542","authenticated-orcid":false,"given":"Caroline","family":"Anselmi","sequence":"additional","affiliation":[{"name":"Department of Cariology Restorative Sciences and Endodontics School of Dentistry University of Michigan  Ann Arbor Michigan USA"},{"name":"Department of Morphology and Pediatric Dentistry School of Dentistry S\u00e3o Paulo State University  Araraquara S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5748-5040","authenticated-orcid":false,"given":"Igor Paulino M.","family":"Soares","sequence":"additional","affiliation":[{"name":"Department of Cariology Restorative Sciences and Endodontics School of Dentistry University of Michigan  Ann Arbor Michigan USA"},{"name":"Department of Dental Materials and Prosthodontics School of Dentistry S\u00e3o Paulo State University  Araraquara S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5866-7137","authenticated-orcid":false,"given":"Alexandre Henrique dos","family":"Reis\u2010Prado","sequence":"additional","affiliation":[{"name":"Department of Cariology Restorative Sciences and Endodontics School of Dentistry University of Michigan  Ann Arbor Michigan USA"},{"name":"Department of Restorative Dentistry School of Dentistry Universidade Federal de Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1593-7926","authenticated-orcid":false,"given":"Pedro Henrique Chaves de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Cariology Restorative Sciences and Endodontics School of Dentistry University of Michigan  Ann Arbor Michigan USA"},{"name":"Department of Preventive and Restorative Dentistry School of Dentistry S\u00e3o Paulo State University  Ara\u00e7atuba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8740-2464","authenticated-orcid":false,"given":"Marco C.","family":"Bottino","sequence":"additional","affiliation":[{"name":"Department of Cariology Restorative Sciences and Endodontics School of Dentistry University of Michigan  Ann Arbor Michigan USA"},{"name":"Department of Biomedical Engineering College of Engineering University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60031-2"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12221"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3TB03070A"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.13581"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21103442"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2741\/e281"},{"key":"e_1_2_8_8_1","first-page":"51","article-title":"Odontoblast Differentiation","volume":"39","author":"Ruch J. 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