{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:36:43Z","timestamp":1760661403659,"version":"build-2065373602"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003693","name":"Korea Institute of Science and Technology","doi-asserted-by":"publisher","award":["2E32860","2E32911"],"award-info":[{"award-number":["2E32860","2E32911"]}],"id":[{"id":"10.13039\/501100003693","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004332","name":"Seoul National University Hospital","doi-asserted-by":"publisher","award":["04\u20102020\u20100530"],"award-info":[{"award-number":["04\u20102020\u20100530"]}],"id":[{"id":"10.13039\/501100004332","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Post\u2010neurosurgical dura reconstruction is crucial for preventing CSF leakage and reducing infection risk. When primary closure is not possible, synthetic and semisynthetic dura substitutes are commonly used, but postoperative adhesions remain a major complication, particularly in reoperations for brain tumors and spinal surgeries. To address this, the use of initiated chemical vapor deposition (iCVD) is investigated to create a polymer\u2010coated dura substitute that minimizes adhesions. iCVD, a dry, solvent\u2010free technique, enables uniform polymer film deposition at low temperatures, ensuring biocompatibility and purity. A widely used dura substitute (Lyoplant) is coated with three biocompatible polymers (pHEMA, EGDMA, V4D4) and assessed cytotoxicity using fibroblasts. Adhesion levels are compared in vitro, and an intracranial adhesion model in mice is used for in vivo evaluation. All polymers exhibit minimal cytotoxicity, with pHEMA showing the least adhesion in vitro and selected for further testing. The uncoated dura causes severe adhesion to the cortex, leading to gross damage, whereas the pHEMA\u2010coated dura prevents adhesion in 90% of cases. Histological analysis reveals inflammatory cell infiltration beneath the uncoated dura. These findings suggest that polymer\u2010coated dura substitutes may reduce reoperation risks and improve patient recovery. Further studies are needed to assess long\u2010term safety for clinical application.<\/jats:p>","DOI":"10.1002\/mabi.202500171","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T14:10:36Z","timestamp":1748268636000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A New Polymer\u2010Coated Xenogeneic Extracellular Matrix to Prevent Postoperative Adhesion Readily Applicable in the Clinic"],"prefix":"10.1002","volume":"25","author":[{"given":"Kyung Hyun","family":"Kim","sequence":"first","affiliation":[{"name":"Neural Development and Anomaly Laboratory Department of Anatomy and Cell Biology Seoul National University College of Medicine  Seoul 03080 Republic of Korea"},{"name":"Division of Pediatric Neurosurgery Seoul National University Children's Hospital Seoul National University College of Medicine  Seoul 03080 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Younghak","family":"Cho","sequence":"additional","affiliation":[{"name":"Brain Science Institute Korea Institute of Science and Technology (KIST)  Seoul 02792 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunyoung","family":"Choi","sequence":"additional","affiliation":[{"name":"Brain Science Institute Korea Institute of Science and Technology (KIST)  Seoul 02792 Republic of Korea"},{"name":"Department of Chemical and Biomolecular Engineering Korea Advanced Institute of Science and Technology (KAIST)  Daejeon 34141 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seeun","family":"Jeon","sequence":"additional","affiliation":[{"name":"Neural Development and Anomaly Laboratory Department of Anatomy and Cell Biology Seoul National University College of Medicine  Seoul 03080 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun Jin","family":"Lee","sequence":"additional","affiliation":[{"name":"Neural Development and Anomaly Laboratory Department of Anatomy and Cell Biology Seoul National University College of Medicine  Seoul 03080 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyejeong","family":"Seong","sequence":"additional","affiliation":[{"name":"Brain Science Institute Korea Institute of Science and Technology (KIST)  Seoul 02792 Republic of Korea"},{"name":"Division of Bio\u2010Medical Science and Technology University of Science and Technology (UST)  Seoul 02792 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0464-7605","authenticated-orcid":false,"given":"Ji Yeoun","family":"Lee","sequence":"additional","affiliation":[{"name":"Neural Development and Anomaly Laboratory Department of Anatomy and Cell Biology Seoul National University College of Medicine  Seoul 03080 Republic of Korea"},{"name":"Division of Pediatric Neurosurgery Seoul National University Children's Hospital Seoul National University College of Medicine  Seoul 03080 Republic of Korea"},{"name":"Genomic Medical Institute Medical Research Center Seoul National University College of Medicine  Seoul 03080 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,26]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_9_1_1","DOI":"10.1016\/j.jneumeth.2008.02.018"},{"doi-asserted-by":"publisher","key":"e_1_2_9_1_2","DOI":"10.1007\/s00586-014-3326-7"},{"doi-asserted-by":"publisher","key":"e_1_2_9_2_1","DOI":"10.1007\/s00381-022-05486-8"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","DOI":"10.1177\/20417314241228118","volume":"15","author":"Khurana D.","year":"2024","journal-title":"J. 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