{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T15:42:33Z","timestamp":1783438953424,"version":"3.54.6"},"reference-count":47,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T00:00:00Z","timestamp":1748131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62305121"],"award-info":[{"award-number":["62305121"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82402441"],"award-info":[{"award-number":["82402441"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Abdominal wall defects are predisposed to life\u2010threatening complications. Biocompatible hernia patches are crucial for the effective repair and reconstruction of abdominal wall defects. However, conventional polymer\u2010based hernia patches are prone to inducing inflammation and reaction to foreign body. The biomimetic Silk@Extracellular Matrix (S@ECM) patch is composed of naturally derived silk and extracellular matrix. The mechanical properties of S@ECM are provided by silk as the template and the incorporation of ECM facilitates cell adhesion and proliferation. Thus, S@ECM patch leads to the abilities of anti\u2010adhesion and rapid reconstruction of the abdominal wall by recruiting cells. In vitro experiments using mechanical property tests demonstrate excellent mechanical properties (8.0 \u00b1 0.1\u00a0MPa). In vivo experiments using a rat abdominal wall defect model demonstrate outstanding resistance to adhesions and rapid repair of the abdominal wall. The biomimetic S@ECM patch offers excellent therapeutic effects on abdominal wall defects, anti\u2010adhesion effects and accelerates the repair of abdominal wall defects through in biomimetic reconstruction of abdominal wall defects. It offers significant values for repairing abdominal wall defects and provides design ideas for repairing other soft tissues.<\/jats:p>","DOI":"10.1002\/mabi.202500209","type":"journal-article","created":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T23:30:50Z","timestamp":1748215850000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Biomimetic Anti\u2010Adhesion Silk@Extracellular Matrix Composite Patch for the Treatment of Abdominal Wall Defects"],"prefix":"10.1002","volume":"25","author":[{"given":"Long","family":"Qi","sequence":"first","affiliation":[{"name":"State Key Laboratory of New Textile Materials &amp; Advanced Processing Technology Wuhan Textile University  Wuhan 430200 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Bioengineering and Health Wuhan Textile University  Wuhan Hubei 430200 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yue","sequence":"additional","affiliation":[{"name":"College of Materials Science and Engineering Wuhan Textile University  Wuhan 430200 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan 430022 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyao","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of New Textile Materials &amp; Advanced Processing Technology Wuhan Textile University  Wuhan 430200 China"},{"name":"School of Bioengineering and Health Wuhan Textile University  Wuhan Hubei 430200 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangjie","family":"Pu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of New Textile Materials &amp; Advanced Processing Technology Wuhan Textile University  Wuhan 430200 China"},{"name":"School of Bioengineering and Health Wuhan Textile University  Wuhan Hubei 430200 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqiang","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of New Textile Materials &amp; Advanced Processing Technology Wuhan Textile University  Wuhan 430200 China"},{"name":"School of Bioengineering and Health Wuhan Textile University  Wuhan Hubei 430200 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjun","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of New Textile Materials &amp; Advanced Processing Technology Wuhan Textile University  Wuhan 430200 China"},{"name":"College of Materials Science and Engineering Wuhan Textile University  Wuhan 430200 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6686-2995","authenticated-orcid":false,"given":"Zhaowei","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of New Textile Materials &amp; Advanced Processing Technology Wuhan Textile University  Wuhan 430200 China"},{"name":"School of Bioengineering and Health Wuhan Textile University  Wuhan Hubei 430200 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoyun","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of New Textile Materials &amp; Advanced Processing Technology Wuhan Textile University  Wuhan 430200 China"},{"name":"School of Bioengineering and Health Wuhan Textile University  Wuhan Hubei 430200 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,25]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2018.10.024"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2023.100691"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-019-1530-4"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-020-02800-3"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","unstructured":"A.Mangram O. F.Oguntodu F.Rodriguez R.Rassadi M.Haley C. J.Shively J. K.Dzandu JSLS2014 18 2014.00229.","DOI":"10.4293\/JSLS.2014.00229"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10029-020-02293-5"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2019.115552"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c09089"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.132282"},{"key":"e_1_2_9_10_1","first-page":"13","volume":"33","author":"Jiao Y. J.","year":"2023","journal-title":"Adv. Funct. Mater."},{"key":"e_1_2_9_11_1","first-page":"37","volume":"13","author":"Liang K. W.","year":"2024","journal-title":"Adv. Healthcare Mater."},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.34133\/bmr.0017"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42765-022-00144-9"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4TB00386A"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2022.103385"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2019.11.050"},{"key":"e_1_2_9_17_1","first-page":"37","volume":"34","author":"Lin D. M.","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-87550-y"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202000735"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2012.09.043"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.554257"},{"key":"e_1_2_9_22_1","first-page":"494","volume":"34","author":"Noro J.","year":"2024","journal-title":"Bioact. Mater."},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-020-00522-z"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07865-9"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.1c00022"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.125556"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compositesb.2021.109524"},{"key":"e_1_2_9_28_1","first-page":"29","volume":"0916","author":"Jiang H.","year":"2025","journal-title":"Biomaterials"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.111160"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00181.2024"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.1c00118"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2020.06.031"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.01.057"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtchem.2021.100655"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.34671"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2024.101032"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S416049"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42765-022-00165-4"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering10080913"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2020.08.036"},{"key":"e_1_2_9_41_1","first-page":"13","volume":"31","author":"Yin X. Y.","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"e_1_2_9_42_1","first-page":"25","volume":"8","author":"Tehrani F. D.","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/life13020317"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1080\/09205063.2018.1433419"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crfs.2024.100865"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2021.112145"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2023.10.054"}],"container-title":["Macromolecular Bioscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mabi.202500209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T10:01:12Z","timestamp":1757930472000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mabi.202500209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,25]]},"references-count":47,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/mabi.202500209"],"URL":"https:\/\/doi.org\/10.1002\/mabi.202500209","archive":["Portico"],"relation":{},"ISSN":["1616-5187","1616-5195"],"issn-type":[{"value":"1616-5187","type":"print"},{"value":"1616-5195","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,25]]},"assertion":[{"value":"2025-04-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00209"}}