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Enhancing these attributes requires precise, cost\u2010effective chemical modification of the biomass material. Herein, a chemical\u2010free approach to transform biomass DNA from onion into DNA nanodots (DNA Dots) that serve as cross\u2010linking cores, chemically bonded with polyethylene glycol diacrylate (PEGDA) through Michael addition, is presented. Using glycerol as the organic liquid phase, the DNA Dot\u2010PEGDA conjugate is formulated into an organogel with exceptional mechanical strength to withstand autoclave sterilization, exhibits antifreeze properties, and sustainably delivers Insulin at the wound site to accelerate healing. Besides cross\u2010linking, the DNA Dots\u2019 rich photophysical properties enable fluorescent tracking of the organogel and generate reactive oxygen species (ROS) under visible light irradiation, maintaining antibiotic\u2010free sterility. While controlled ROS generation inhibits bacterial growth, biocompatibility is not compromised. The newly formulated organogel expedites the healing process in normal and diabetic conditions as tested using HEKa cells. This represents the first example of converting biomass DNA into nanodots to develop a multifunctional organogel that is autoclavable, anti\u2010freezing, trackable, and capable of delivering growth factor while simultaneously generating and scavenging ROS for potential wound healing applications.<\/jats:p>","DOI":"10.1002\/mabi.202500265","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T03:54:12Z","timestamp":1760673252000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["An Autoclavable, Antifreezing, Fluorescent Biomass Derived DNA Dot Organogel for Simultaneous Self\u2010Sterilization, ROS Regulation and Growth Factor Delivery in Wound Healing Application"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5848-3707","authenticated-orcid":false,"given":"Maansi","family":"Aggarwal","sequence":"first","affiliation":[{"name":"Department of 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