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This study presents a scaffold\u2010free extrusion\u2010based 3D bioprinting (E3DB) approach to fabricate cornea constructs without support materials or molds. Bioinks composed of decellularized corneal extracellular matrix (dCECM), sodium alginate (SA), and type B gelatin (TBG) were formulated and evaluated for rheological performance, including viscosity, shear thinning, and viscoelasticity. Among the tested formulations, bioink 3G10 (SA: 3%, dCECM: 6\/mL, TBG: 10%; 2:1:1 ratio) demonstrated optimal rheological and printability performance, enabling the fabrication of stable, curvature\u2010preserving constructs. The printed constructs exhibited high shape fidelity, light transmittance comparable to native cornea, and Young's modulus values within the physiological range. Human placenta\u2010derived mesenchymal stem cells (hPMSCs) encapsulated in bioink 3G10 showed high initial viability, a transient decline at day 7, and recovery by day 14, accompanied by morphological elongation. Gene expression analysis revealed marked upregulation of keratocyte\u2010specific markers (KERA and ALDH) and suppression of ACTA2, indicating progression toward a keratocyte\u2010like phenotype. These findings underscore the suitability of hPMSCs and dCECM\u2010based bioinks for scaffold\u2010free cornea bioprinting, providing a robust platform for the development of anatomically accurate and biologically functional corneal grafts.<\/jats:p>","DOI":"10.1002\/mabi.202500276","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T10:30:38Z","timestamp":1757586638000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Scaffold\u2010Free Extrusion\u2010Based 3D Bioprinting of Cornea Constructs Using a Decellularized Corneal Extracellular Matrix Based Bioink and Human Placenta\u2010Derived Mesenchymal Stem Cells"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8897-7920","authenticated-orcid":false,"given":"Hugo A.","family":"Marin\u2010Tapia","sequence":"first","affiliation":[{"name":"Rheology Nanofluids and Microfluidics Laboratory Faculty of Sciences Autonomous University of the State of Mexico Campus Universitario \u2018\u2018El Cerrillo, Piedras Blancas\u201d, Carretera Toluca\u2010Ixtlahuaca km 15.5, C.P. Estado de M\u00e9xico Mexico"},{"name":"Doctorate in Science student, Autonomous University of the State of Mexico Faculty of Sciences Campus Universitario \u2018\u2018El Cerrillo, Piedras Blancas\u201d Carretera Toluca\u2010Ixtlahuaca km 15.5, C.P. Estado de M\u00e9xico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2174-4845","authenticated-orcid":false,"given":"Lorena","family":"Romero\u2010Salazar","sequence":"additional","affiliation":[{"name":"Nanothermodynamics and Complex Systems Laboratory Autonomous University of the State of Mexico Faculty of Sciences Campus Universitario \u2018\u2018El Cerrillo, Piedras Blancas\u201d Carretera Toluca\u2010Ixtlahuaca km 15.5, C.P. 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