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Therefore, we aim to design an H\n                    <jats:sub>2<\/jats:sub>\n                    S\u2010releasing resorbable synthetic graft that utilizes the therapeutic benefits of the H\n                    <jats:sub>2<\/jats:sub>\n                    S to modulate the graft regeneration. To ease fabrication of the H\n                    <jats:sub>2<\/jats:sub>\n                    S\u2010releasing graft, we have designed a pair of functional polyesters that are electrospinnable and photocurable to form an elastic fibrous conduit. The conduit bears free thiol groups that are conjugated with a methacrylated H\n                    <jats:sub>2<\/jats:sub>\n                    S donor through thiol\u2010ene click chemistry to form an H\n                    <jats:sub>2<\/jats:sub>\n                    S\u2010releasing graft. The graft can sustainably release H\n                    <jats:sub>2<\/jats:sub>\n                    S over \u223c12 days\n                    <jats:italic>in vitro<\/jats:italic>\n                    . Differing from prior designs, the H\n                    <jats:sub>2<\/jats:sub>\n                    S\u2010releasing graft simultaneously possesses key features of a robust elasticity,\u00a0and suitable mechanical properties, degradation rate and porosity. At the proof\u2010of\u2010concept stage, we examined the H\n                    <jats:sub>2<\/jats:sub>\n                    S stimulation on endothelial cell growth using the graft with a low H\n                    <jats:sub>2<\/jats:sub>\n                    S releasing rate. The results demonstrated that the graft with sustained H\n                    <jats:sub>2<\/jats:sub>\n                    S release could significantly promote endothelial cell growth\n                    <jats:italic>in vitro<\/jats:italic>\n                    . This work paved the way for\n                    <jats:italic>in vivo<\/jats:italic>\n                    evaluation of the H\n                    <jats:sub>2<\/jats:sub>\n                    S\u2010releasing graft.\n                  <\/jats:p>","DOI":"10.1002\/mabi.202500308","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T18:34:46Z","timestamp":1758566086000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Biodegradable Synthetic Graft with Sustained Hydrogen Sulfide Release Promotes Endothelial Cell Growth"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7908-7329","authenticated-orcid":false,"given":"Xiaochu","family":"Ding","sequence":"first","affiliation":[{"name":"Health Research Institute Michigan Technological University  1400 Townsend Drive Houghton Michigan USA"},{"name":"Department of Chemistry Michigan Technological University 1400 Townsend Drive Houghton Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying Grace","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Henry M. Rowan College of Engineering Rowan University 201 Mullica Hill Road Glassboro New Jersey USA"},{"name":"Cardiovascular Institute Rowan\u2010Virtua School of Translational Biomedical Engineering &amp; Sciences Rowan University 201 Mullica Hill Road Glassboro New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethan","family":"Goltz","sequence":"additional","affiliation":[{"name":"Health Research Institute Michigan Technological University  1400 Townsend Drive Houghton Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narangerel","family":"Gantumur","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Henry M. Rowan College of Engineering Rowan University 201 Mullica Hill Road Glassboro New Jersey USA"},{"name":"Cardiovascular Institute Rowan\u2010Virtua School of Translational Biomedical Engineering &amp; Sciences Rowan University 201 Mullica Hill Road Glassboro New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce P.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Michigan Technological University 1400 Townsend Drive Houghton Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.04.052"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2016.76"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2013.77"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2015.0100"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2017.08.035"},{"key":"e_1_2_8_7_1","first-page":"1","article-title":"Readily Available Tissue\u2010Engineered Vacular Grafts","volume":"3","author":"Dahl S. 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