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In this study, electrically conductive hydrogels with dual functionality were developed for accelerated wound healing and motion sensing applications. The hydrogel electrodes were synthesized via a freeze\u2013thaw cross\u2010linking method using polyvinyl alcohol (PVA), crystalline nanocellulose (CNC), Laponite (LAP), and polyaniline (PANI). The influence of CNC and LAP content on the electrical conductivity, mechanical strength, swelling capacity, and degradation behavior of the hydrogels was systematically investigated. The PVA\u2013CNC\u2013LAP\/PANI hydrogel optimized for electrical conductivity (1.5 wt.% CNC and 1.25 wt.% LAP) demonstrated outstanding multifunctional performance, combining robust mechanical strength (490 kPa tensile strength, 2.57 mm\/mm elongation, 162 kPa elastic modulus, and 656 kJ\/m\n                    <jats:sup>3<\/jats:sup>\n                    toughness) with excellent electrical properties, including high conductivity (33.65 S\/m), reliable sensitivity (gauge factor = 1.74), and remarkable durability (&gt;500 cycles at 20% strain). Biocompatibility and cell migration potential of this hydrogel electrode were assessed through scratch assays using human dermal fibroblasts (HDF). Additionally, the hydrogel's performance was evaluated in flexible sensor, smart finger actuator, and electrocardiogram (ECG) electrode applications. The biocompatible PVA\/CNC\/PANI\u2010LAP hydrogel electrodes exhibited satisfactory electrical conductivity, excellent mechanical integrity, and electroresponsive behavior, thereby effectively supporting HDF proliferation, directed migration, and motion detection capabilities.\n                  <\/jats:p>","DOI":"10.1002\/mabi.202500409","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T13:09:09Z","timestamp":1763730549000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Development of Dual\u2010Functional Hydrogel\u2010Based Conductive Electrodes for Accelerated Wound Healing and Motion Sensing"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5019-2010","authenticated-orcid":false,"given":"Cihangir","family":"Boztepe","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Faculty of Engineering Inonu University  Malatya T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u0131rat Orhan","family":"Bulucu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Faculty of Engineering Inonu University  Malatya T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reyhan","family":"Zengin","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Faculty of Engineering Inonu University  Malatya T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,21]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"8","article-title":"Physiology of the Skin","volume":"40","author":"McKnight G.","year":"2020","journal-title":"Surgery"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16155"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.446"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2021.0026"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13671-017-0192-7"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12683"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-019-6319-6"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12080735"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202100557"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-018-2830-1"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/JMDH.S127207"},{"key":"e_1_2_8_13_1","first-page":"634","article-title":"Bioelectric Dressing Technologies for Wound Healing: Advances and Clinical Perspectives","volume":"8","author":"Farber P. 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