{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:39:19Z","timestamp":1773016759214,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T00:00:00Z","timestamp":1762646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T00:00:00Z","timestamp":1762646400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Polyurethanes and their composites are versatile materials widely used in numerous medical applications. However, limited information is available regarding their copper composites. Copper is a trace element in the human body that functions as an enzyme cofactor in both normal and pathological angiogenesis, as well as in muscle and brain formation. Considering this, copper complexes of D\u2010penicillamine (DP), L\u2010cysteine (LC), and dopamine (DOP) were incorporated into segmented polyurethanes (SPU) synthesized with either a semi\u2010crystalline (poly\u2010\u03b5\u2010caprolactone, PCL) or an amorphous (polytetramethylene ether glycol, PTMEG) soft segment. FTIR and Raman revealed new absorptions and peak shifts, confirming the presence of the complexes within the matrix of all composites. XPS further corroborated the presence of copper and sulfur. The crystallinity of the PCL\u2010based polyurethanes was influenced by the addition of the filler, as observed through DSC and DRX. Furthermore, TGA analysis indicated the emergence of new decomposition temperatures following the incorporation of copper complexes. In general, no significant reduction in Young's modulus was observed, except for certain composites containing DPENCUII as filler, which exhibited a slight increase compared to pristine SPU\u00b4s. Finally, the composites demonstrated neither hemolytic nor procoagulating behavior (hemolysis &lt; 5% and BCI &gt; 20), although they exhibited some degree of impairment in cytocompatibility compared to their respective pristine SPUs. Collectively, these findings suggest that some composites possess promising properties for potential cardiovascular applications.<\/jats:p>","DOI":"10.1002\/mabi.202500419","type":"journal-article","created":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T18:40:06Z","timestamp":1762713606000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Polyurethane Structure on the Physicochemical, Mechanical, and Biological Properties on their Copper Complexes Composites"],"prefix":"10.1002","volume":"26","author":[{"given":"Guido Antonio","family":"Zapata\u2010Catzin","sequence":"first","affiliation":[{"name":"Unidad de Materiales Centro de Investigaci\u00f3n Cient\u00edfica de Yucat\u00e1n  M\u00e9rida Yucat\u00e1n M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rossana Faride","family":"Vargas\u2010Coronado","sequence":"additional","affiliation":[{"name":"Unidad de Materiales Centro de Investigaci\u00f3n Cient\u00edfica de Yucat\u00e1n  M\u00e9rida Yucat\u00e1n M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuel","family":"Ceballos\u2010Gongora","sequence":"additional","affiliation":[{"name":"Laboratorio de Farmacolog\u00eda, Facultad de Qu\u00edmica Universidad Aut\u00f3noma de Yucat\u00e1n  M\u00e9rida Yucat\u00e1n M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor Ermilo","family":"Arana\u2010Arg\u00e1ez","sequence":"additional","affiliation":[{"name":"Laboratorio de Farmacolog\u00eda, Facultad de Qu\u00edmica Universidad Aut\u00f3noma de Yucat\u00e1n  M\u00e9rida Yucat\u00e1n M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eustolia","family":"Rodr\u00edguez\u2010Vel\u00e1zquez","sequence":"additional","affiliation":[{"name":"Centro de Graduados e Investigaci\u00f3n en Qu\u00edmica Grupo de Biomateriales y Nanomedicina Tecnol\u00f3gico Nacional de M\u00e9xico\/Instituto Tecnol\u00f3gico de Tijuana  Tijuana Baja California M\u00e9xico"},{"name":"Facultad de Odontolog\u00eda Universidad Aut\u00f3noma de Baja California  Tijuana Baja California M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Alatorre\u2010Meda","sequence":"additional","affiliation":[{"name":"SECIHTI\u2010Centro de Graduados e Investigaci\u00f3n en Qu\u00edmica Grupo de Biomateriales y Nanomedicina Tecnol\u00f3gico Nacional de M\u00e9xico\/Instituto Tecnol\u00f3gico de Tijuana  Tijuana Baja California M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gloria Mar\u00eda","family":"Molina\u2010Salinas","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica de Yucat\u00e1n Instituto Mexicano del Seguro Social (IMSS)  M\u00e9rida Yucat\u00e1n M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9s","family":"Uc\u2010Cachon","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica de Yucat\u00e1n Instituto Mexicano del Seguro Social (IMSS)  M\u00e9rida Yucat\u00e1n M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Gallardo","sequence":"additional","affiliation":[{"name":"Polymer Functionalization Group (FUPOL) Institute of Polymer Science and Technology, ICTP\u2010CSIC  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Copes","sequence":"additional","affiliation":[{"name":"Laboratory for Biomaterials and Bioengineering (CRC\u2010I) Department of Mining, Metallurgy and Materials Engineering &amp; CHU de Quebec Research Center Laval University  Quebec City Quebec QC G1V0A6 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Mantovani","sequence":"additional","affiliation":[{"name":"Laboratory for Biomaterials and Bioengineering (CRC\u2010I) Department of Mining, Metallurgy and Materials Engineering &amp; CHU de Quebec Research Center Laval University  Quebec City Quebec QC G1V0A6 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0809-7794","authenticated-orcid":false,"given":"Juan Valerio","family":"Cauich\u2010Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Unidad de Materiales Centro de Investigaci\u00f3n Cient\u00edfica de Yucat\u00e1n  M\u00e9rida Yucat\u00e1n M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01229-y"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2021.03.003"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2020.09.044"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.4172\/2161-0444.1000445"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2023.100647"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2023.114704"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2020.10.004"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152009787313837"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201041063\u2010x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2015.01.005"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2022.214756"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/09205063.2022.2155783"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pat.5062"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmrt.2023.04.243"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seppur.2020.117148"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2021.129979"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtcomm.2020.101894"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09946-9"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma9070544"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5b08665"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matpr.2017.01.196"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5b09738"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmrt.2022.06.115"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymertesting.2019.105955"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2020.104765"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856\u2010018\u20106165\u2010y"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12221-019-8735-0"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.07.020"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2016.10.019"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/14686996.2020.1718549"},{"key":"e_1_2_10_32_1","volume-title":"Biological Evaluation of Medical Devices \u2014 Part 5: Tests for In Vitro Cytotoxicity","author":"ISO 10993\u20135:2009(E)","year":"2009"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.2144\/04373ST05"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.3906\/biy-1703-104"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2016.11.005"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.75"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2017.07.027"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm401541v"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano11081981"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym16101314"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/pc.24654"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-4332(99)00319-0"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/cof.FBIOE.2016.01.02580"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/pc.27105"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/mame.202500100"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1080\/1023666X.2020.1766786"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2013.10.070"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2019.01.092"}],"container-title":["Macromolecular Bioscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mabi.202500419","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mabi.202500419","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mabi.202500419","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:49:39Z","timestamp":1773013779000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mabi.202500419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,9]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/mabi.202500419"],"URL":"https:\/\/doi.org\/10.1002\/mabi.202500419","archive":["Portico"],"relation":{},"ISSN":["1616-5187","1616-5195"],"issn-type":[{"value":"1616-5187","type":"print"},{"value":"1616-5195","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,9]]},"assertion":[{"value":"2025-07-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00419"}}