{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:18:05Z","timestamp":1772990285381,"version":"3.50.1"},"reference-count":63,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:00:00Z","timestamp":1770508800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006595","name":"Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii","doi-asserted-by":"publisher","award":["83PED"],"award-info":[{"award-number":["83PED"]}],"id":[{"id":"10.13039\/501100006595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The skin is constantly exposed to external factors throughout a person's life, ultraviolet (UV) radiation being one of the most harmful. The primary defence against UV\u2010induced damage is skin pigmentation, which is achieved through the synthesis of melanin. However, overproduction of melanin can lead to skin disorders such as pigment spots, melasma, and even melanoma. Therefore, the present study aimed to obtain a new multifunctional bioactive system (MBS) starting from a supramolecular co\u2010assembled gel (SG) based on amino acids and short peptides enhanced with a glycoside\u2010pyrone\u2010based complex (arbutin\u2010kojic acid), presenting an inhibitory effect on peroxidase and implicitly controlling melanin production. The MBS gel was physicochemically analyzed using FTIR to observe changes in its chemical structure after exposure to 4\u00b0C and 25\u00b0C. The results indicate that MBS remains stable for up to 12 weeks without chemical changes in structure when stored at 4\u00b0C. The potential applicability was evaluated by antioxidant activity, where the gel exhibited above 85% scavenging activity of DPPH\u00b7 free radicals. The MBS displays synergistically strong ability to inhibit the catalytic activity, functioning as an uncompetitive inhibitor that binds specifically to the enzyme\u2010substrate complex. The in vivo biosafety of the MBS was determined at 24 h and 7 days after rat administration. The hematological and biochemical parameters show that the MBS system is safe and biocompatible both after 24 h and after 7 days. The overall findings suggest that the MBS gel has promising potential as a regulator of melanogenesis by inhibiting skin melanin synthesis.<\/jats:p>","DOI":"10.1002\/mabi.202500454","type":"journal-article","created":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T19:20:36Z","timestamp":1770578436000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preparation and Evaluation of the Synergistic Benefits of a Glycoside\u2010Pyrone\u2010Based Multifunctional System as a Possible Regulator for Melanogenesis"],"prefix":"10.1002","volume":"26","author":[{"given":"Alexandra","family":"Vieru","sequence":"first","affiliation":[{"name":"\u201cPetru Poni\u201d Institute of Macromolecular Chemistry Romanian Academy  Iasi Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alina Gabriela","family":"Rusu","sequence":"additional","affiliation":[{"name":"\u201cPetru Poni\u201d Institute of Macromolecular Chemistry Romanian Academy  Iasi Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alina","family":"Ghilan","sequence":"additional","affiliation":[{"name":"\u201cPetru Poni\u201d Institute of Macromolecular Chemistry Romanian Academy  Iasi Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliana","family":"Mititelu\u2010Tartau","sequence":"additional","affiliation":[{"name":"Pharmacology, Clinical Pharmacology and Algesiology Department Faculty of Medicine University of Medicine and Pharmacy \u201cGrigore T. 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