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Although bioactive peptide hydrogels have been widely evaluated for tissue engineering applications, their potential in 3D cancer models has been confirmed in only a few studies. In this study, self\u2010assembling peptide hydrogels containing LDV (IBP1) and LDV and IKVAV cell attachment motifs (IBP2), and the control hydrogel without adhesion units (KLEI) were used for lung cancer modeling. The peptides self\u2010assembled into hydrogels in a cell culture medium with storage moduli of \u223c700\u20131500 Pa. The IBP1 and IBP2 hydrogels enhanced A549 cell proliferation and induced the formation of spheroids with average diameters between \u223c70 and \u223c150 \u00b5m. The cells in KLEI hydrogel with the highest stiffness exhibited mesenchymal\u2010type migration, independent of the cell population, whereas transformation to mesenchymal migration necessitated a specific cell population in the IBP2 hydrogel. The cells in the IBP1 and IBP2 hydrogels with enhanced cell\u2010cell interactions demonstrated higher resistance to docetaxel (DTX). Thus, our results indicate that these bioactive hydrogels can serve as a promising platform for in vitro assessment of cancer mechanisms and drug screening.<\/jats:p>","DOI":"10.1002\/mabi.202500493","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T04:38:34Z","timestamp":1770698314000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Self\u2010Assembled Peptide Hydrogels with Cell Attachment Motifs for 3D Lung Cancer Model: Evaluation of Cell\u2010Matrix Interactions and Drug Response"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7024-6282","authenticated-orcid":false,"given":"Burcu","family":"S\u0131rma Tar\u0131m","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering \u0130zmir Institute of Technology  Izmir 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