{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T09:56:26Z","timestamp":1789638986232,"version":"4.0.0"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100011901","name":"Rajiv Gandhi Science and Technology Commission, Government of Maharashtra","doi-asserted-by":"publisher","award":["RGSTC\/File\u20102025\/DPP\u2010355\/CR\u201027\/160"],"award-info":[{"award-number":["RGSTC\/File\u20102025\/DPP\u2010355\/CR\u201027\/160"]}],"id":[{"id":"10.13039\/501100011901","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Quercetin (Qt) exhibits significant neuroprotective potential in Alzheimer's disease; however, its clinical translation is limited by poor solubility, low permeability, and inadequate brain bioavailability. In this study, a modified polymeric nanocarrier was developed to enhance Qt delivery to the brain. Polyethyleneimine (PEI) was conjugated with polyethylene glycol (PEG) and further functionalized with phenylalanine to reduce PEI\u2010associated toxicity and improve brain\u2010targeting efficiency. Successful polymer synthesis was confirmed by FT\u2013IR spectroscopy, showing characteristic S\u2500S bond formation at 790 cm\n                    <jats:sup>\u2212<\/jats:sup>\n                    <jats:sup>1<\/jats:sup>\n                    , mass spectrometry (m\/z 1087.3), and differential scanning calorimetry. Nanoparticles were optimized using a Quality by Design approach, yielding an experimental particle size of 161.4 \u00b1 1.10\u00a0nm, zeta potential of 15.9 \u00b1 2.5\u00a0mV, and high entrapment efficiencies of 84.21 % and 86.74 % for Qt\u2010PEI\u2010Np and Qt\u2010PEI\u2010PEG\u2010S\u2010S\u2010AA\u2010Np, respectively. SEM analysis revealed spherical nanoparticles with nanoscale surface roughness and good stability. In vitro release studies demonstrated sustained Qt release (98 % over 48\u00a0h). MTT assays and cytokine analysis (TNF\u2010\u03b1, IL\u20101\u03b2, IL\u20106) confirmed biocompatibility. Enhanced intestinal permeability, absence of hippocampal toxicity, and effective BBB transport further support the potential of this nanocarrier for targeted neurotherapeutic delivery.\n                  <\/jats:p>","DOI":"10.1002\/mabi.202500503","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T14:42:08Z","timestamp":1769179328000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Targeted Delivery of Quercetin to the Brain via a Modified Polymeric Nanocarrier"],"prefix":"10.1002","volume":"26","author":[{"given":"Priyanshu","family":"Bhadane","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry School of Pharmacy &amp; Technology Management Mukesh Patel Technology Park SVKM's NMIMS University  Shirpur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4000-2587","authenticated-orcid":false,"given":"Aniket","family":"Khairnar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry School of Pharmacy &amp; Technology Management Mukesh Patel Technology Park SVKM's NMIMS University  Shirpur India"},{"name":"Shobhaben Pratapbhai Patel School of Pharmacy &amp; Technology Management SVKM's Narsee Monjee Institute of Management Studies (NMIMS) Deemed to Be University  Mumbai Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1086-4316","authenticated-orcid":false,"given":"Kalpana","family":"Pandya","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry School of Pharmacy &amp; Technology Management Mukesh Patel Technology Park SVKM's NMIMS University  Shirpur India"},{"name":"Shobhaben Pratapbhai Patel School of Pharmacy &amp; Technology Management SVKM's Narsee Monjee Institute of Management Studies (NMIMS) Deemed to Be University  Mumbai Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0224-2348","authenticated-orcid":false,"given":"Anup","family":"Naha","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics Manipal College of Pharmaceutical Sciences Manipal Academy of Higher Education  Manipal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3418-4325","authenticated-orcid":false,"given":"Dileep","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Manipal College of Pharmaceutical Sciences Manipal Academy of Higher Education  Manipal Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8395-3506","authenticated-orcid":false,"given":"K. 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