{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T08:10:02Z","timestamp":1774858202219,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,12,21]],"date-time":"2025-12-21T00:00:00Z","timestamp":1766275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,21]],"date-time":"2025-12-21T00:00:00Z","timestamp":1766275200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100010712","name":"Viet Nam National University Ho Chi Minh City","doi-asserted-by":"publisher","award":["A2024\u201028\u201001"],"award-info":[{"award-number":["A2024\u201028\u201001"]}],"id":[{"id":"10.13039\/501100010712","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study fabricates and characterizes novel double\u2010network hydrogels for 3D bio\u2010ink applications, combining\n                    <jats:italic>N,O<\/jats:italic>\n                    \u2010carboxymethyl chitosan (NOCC), aldehyde hyaluronate (AHy), and alginate (Alg). The initial Schiff base\u2010cross\u2010linked network (NOCC\u2013AHy\u2013Alg) is enhanced with a second ionic Ca\n                    <jats:sup>2+<\/jats:sup>\n                    cross\u2010linking, optimized via an internal suspension method (CaCO\n                    <jats:sub>3<\/jats:sub>\n                    \/glucono\u2010\u03b4\u2010lactone). Optimal parameters are 0.2\u00a0\n                    <jats:sc>m<\/jats:sc>\n                    CaCO\n                    <jats:sub>3<\/jats:sub>\n                    and 0.1\u00a0\n                    <jats:sc>m<\/jats:sc>\n                    glucono\u2010\u03b4\u2010lactone with a 1\u2010h immersion, proving superior to external CaCl\n                    <jats:sub>2<\/jats:sub>\n                    immersion. This internal approach yields a more robust network with improved compressive strength, dimensional stability, and lower porosity, requiring sustained Ca\n                    <jats:sup>2+<\/jats:sup>\n                    for long\u2010term stability. The hydrogels also demonstrate excellent self\u2010recovery and energy dissipation, indicating potential for 3D printing. In vitro studies confirm biocompatibility with L929 and AT\u2010MSCs. Overall, these double\u2010network hydrogels show significant promise as advanced bio\u2010inks for tissue engineering and other biomedical uses.\n                  <\/jats:p>","DOI":"10.1002\/mabi.202500527","type":"journal-article","created":{"date-parts":[[2025,12,21]],"date-time":"2025-12-21T19:11:12Z","timestamp":1766344272000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fabrication of Double\u2010Network Hydrogel Based on\n                    <i>N,O<\/i>\n                    \u2010carboxymethyl chitosan, Aldehyde Hyaluronate, and Alginate for 3D Bio\u2010Ink Applications"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5137-1416","authenticated-orcid":false,"given":"Binh Thanh","family":"Vu","sequence":"first","affiliation":[{"name":"Tissue Engineering and Regenerative Medicine Department School of Biomedical Engineering International University  Ho Chi Minh City 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Thi\u2010Phuong","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Tissue Engineering and Regenerative Medicine Department School of Biomedical Engineering International University  Ho Chi Minh City Vietnam"},{"name":"Vietnam National University  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yen\u2010Nhi","family":"Ha\u2010Nguyen","sequence":"additional","affiliation":[{"name":"Tissue Engineering and Regenerative Medicine Department School of Biomedical Engineering International University  Ho Chi Minh City Vietnam"},{"name":"Vietnam National University  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3390-495X","authenticated-orcid":false,"given":"Nhu\u2010Thuy","family":"Trinh","sequence":"additional","affiliation":[{"name":"Tissue Engineering and Regenerative Medicine Department School of Biomedical Engineering International University  Ho Chi Minh 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