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Hydrogels, with tunable physicochemical properties, biocompatibility, and localized drug delivery capabilities, offer advanced solutions to these problems. This review systematically examines advanced hydrogel\u2010based strategies for IAO treatment, categorized into two primary approaches. Antibiotic\u2010loaded hydrogels leverage nanomaterial integration and hybrid composites to achieve precise, spatiotemporal drug release, thereby minimizing toxicity and resistance. Non\u2010antibiotic approaches, including nanomaterial\u2010based agents such as metals and photothermal nanohybrids, as well as peptides, plant polyphenols, and phage therapy, provide alternative options to circumvent antibiotic resistance. Crucially, we highlight key optimization strategies that encompass controlled cross\u2010linking, stimuli\u2010responsive systems (e.g., pH and temperature), anti\u2010biofilm mechanisms, and biomimicry, synergistically enhancing both antibacterial and osteogenic functions in these platforms. Collectively, these advances signify a shift from passive drug carriers to multifunctional, bioactive platforms that both eradicate resistant bacteria and support bone regeneration. This transformative shift, however, reveals persistent challenges while suggesting promising research avenues for advancing hydrogel\u2010based therapies against IAO.<\/jats:p>","DOI":"10.1002\/mabi.202500528","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T08:37:12Z","timestamp":1766047032000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Antibacterial Agent\u2010Loaded Hydrogels for Implant\u2010Associated Osteomyelitis: A Review"],"prefix":"10.1002","volume":"26","author":[{"given":"Bingcheng","family":"Ji","sequence":"first","affiliation":[{"name":"School of Basic Medical Sciences Shandong Second Medical University  Weifang China"},{"name":"College of Medicine Qingdao Binhai University  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangmin","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences 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