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Currently, the primary treatment for ALI involves intravenous or oral administration of glucocorticoid drugs. However, this approach suffers from low effective drug concentrations reaching the lungs and may cause systemic toxic side effects. Therefore, there is an urgent need to develop novel therapeutic agents and optimized delivery strategies specifically tailored for ALI treatment. On one hand, pravastatin (Prv) exhibits potent anti\u2010inflammatory and antioxidant properties and has demonstrated therapeutic efficacy in ALI treatment, positioning it as a promising drug candidate. However, its underlying mechanisms remain poorly understood. On the other hand, inhalation represents a highly promising delivery approach for ALI therapy by enhancing drug retention in the lungs. Nevertheless, this localized administration strategy still faces the challenge of mucus barrier impeding drug penetration. Herein, a ferritin\u2010based pravastatin nanoassembly (Prv@FTn) was developed to improve the mucus\u2010penetrating ability of Prv. In vitro and in vivo investigations revealed that Prv@FTn alleviates LPS\u2010induced ALI symptoms through inhibition of the Rho\u2010ROCK I\/II signaling pathway. These findings suggest that mucus\u2010penetrating Prv@FTn is a promising Rho\/ROCK signaling pathway inhibitor for ALI therapy.<\/jats:p>","DOI":"10.1002\/mabi.202500549","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T08:26:36Z","timestamp":1768379196000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ferritin\u2010Based Pravastatin Assembly Augments Mucus Penetration and Ameliorates Acute Lung Injury Via Rho\/ROCK Signaling Pathway"],"prefix":"10.1002","volume":"26","author":[{"given":"Ting","family":"Xie","sequence":"first","affiliation":[{"name":"Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals &amp; College of Pharmaceutical Science Zhejiang Key Laboratory of Green, Low\u2010Carbon, and Efficient Development of Marine Fishery Resources Zhejiang University of Technology  Hangzhou 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