{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:20:43Z","timestamp":1783012843491,"version":"3.54.6"},"reference-count":74,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Surface modifications of polycaprolactone (PCL) implants influence osseointegration by altering cell adhesion, proliferation, and differentiation. Osteon\u2010like microtopography has been shown to enhance these parameters compared to untreated PCL. Additional treatments, such as cold atmospheric plasma (CAP) and extracellular matrix (ECM) coatings, may further improve bioactivity. This study evaluates and compares the osteogenic potential of osteon\u2010like microtopography, CAP treatment on non\u2010microstructured PCL, ECM coating on non\u2010microstructured PCL, and their combination. Modified PCL samples were analyzed for cell adhesion, proliferation, and differentiation using primary human mesenchymal stem cells. Compared to osteon\u2010like microtopography, CAP\u2010treated and ECM\u2010coated surfaces the combination of all three increased cell adhesion by nearly two\u2010fold. Cell proliferation followed a similar trend, with the combination treatment showing the greatest enhancement by day 10. Alkaline phosphatase activity peaked with osteon\u2010like microtopography, while mineralization was maximized with the combination treatment. In summary, the integration of osteon\u2010like microtopography with CAP treatment and ECM coating synergistically improves cell adhesion, proliferation, and differentiation, offering a promising strategy for optimizing PCL implants to improve osseointegration.<\/jats:p>","DOI":"10.1002\/mabi.202500597","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T10:27:56Z","timestamp":1777285676000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Enhancing Poly\u2010\u03b5\u2010Caprolactone Implant Performance: Synergistic Surface Modifications With Osteon\u2010Like Microstructure, Cold Atmospheric Plasma, and Extracellular Matrix Coating"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1970-0029","authenticated-orcid":false,"given":"Matthias","family":"Vostatek","sequence":"first","affiliation":[{"name":"Center for Medical Physics and Biomedical Engineering Medical University of Vienna  Vienna Austria"},{"name":"Austrian Cluster for Tissue Regeneration  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elettra","family":"Verin","sequence":"additional","affiliation":[{"name":"Center for Medical Physics and Biomedical Engineering Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marvin","family":"Tamm","sequence":"additional","affiliation":[{"name":"Center for Medical Physics and Biomedical Engineering Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Mehofer","sequence":"additional","affiliation":[{"name":"Department of Engineering, Applied Electronics and Technical Informatics University of Applied Sciences Vienna (FH Campus Wien)  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Wellenzohn","sequence":"additional","affiliation":[{"name":"Department of Engineering, Applied Electronics and Technical Informatics University of Applied Sciences Vienna (FH Campus Wien)  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl H.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Austrian Cluster for Tissue Regeneration  Vienna Austria"},{"name":"Center for Biomedical Research and Translational Surgery Medical University of Vienna  Vienna Austria"},{"name":"Ludwig Boltzmann Institute for Cardiovascular Research  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Toegel","sequence":"additional","affiliation":[{"name":"Karl Chiari Lab for Orthopaedic Biology Department of Orthopedics and Trauma Surgery Medical University of Vienna  Vienna Austria"},{"name":"Ludwig Boltzmann Institute for Arthritis and Rehabilitation  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0279-6615","authenticated-orcid":false,"given":"Francesco","family":"Moscato","sequence":"additional","affiliation":[{"name":"Center for Medical Physics and Biomedical Engineering Medical University of Vienna  Vienna Austria"},{"name":"Austrian Cluster for Tissue Regeneration  Vienna Austria"},{"name":"Ludwig Boltzmann Institute for Cardiovascular Research  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1515\/ntrev\u20102020\u20100076"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24054810"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43246\u2010024\u201000598\u2010x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c03667"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202306534"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.134615"},{"key":"e_1_2_10_8_1","volume-title":"The Osseointegration Book: From Calvarium to Calcaneus","author":"Br\u00e5nemark P. 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