{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:18:36Z","timestamp":1772990316318,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Hydrogels mimicking the mechanical and biochemical features of the cellular microenvironment allow cell encapsulation and facilitate in vitro 3D culture. In addition to biocompatibility and reactivity in physiological conditions, a key criterion for crosslinking chemistry is appropriate gelation kinetics to allow mixing and homogeneous distribution of cells with the hydrogel precursors. We have previously presented aryl methylsulfone\/thiol (MS\/SH) reaction as a thiol\u2010reactive cross\u2010linking system for cell encapsulation in star polyethylene glycol (PEG4) hydrogels with a gelation kinetics in minutes time scale. Remaining experimental challenges for this system are a finer modulation of gelation kinetics and streamlining the synthesis of the prepolymer. Here we present the possibility to tune the gelation kinetics by introducing an electron\u2010withdrawing substituent at\n                    <jats:italic>p\u2010<\/jats:italic>\n                    position of the aryl MS ring. This variant also presents synthetic advantages. We study the influence of the\n                    <jats:italic>p<\/jats:italic>\n                    \u2010substituent on the physicochemical properties of MS\/SH crosslinked hydrogels, and their performance for cell encapsulation. We compare these properties with the PEG\u2010MS variant containing an electron\u2010donating linker. The new star poly(ethylene glycol)\u20104\u2010(5\u2010(methylsulfonyl)\u20101\n                    <jats:italic>H<\/jats:italic>\n                    \u2010tetrazol\u20101\u2010yl)benzamide (PEG4\u2010CONH\u2010TzMS) shows superior properties as cell encapsulating hydrogel in terms of ease of mixing polymer precursors, faster gelation, homogenous cell distribution and high enzymatic stability.\n                  <\/jats:p>","DOI":"10.1002\/mabi.202500627","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T10:13:29Z","timestamp":1772964809000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Thiol\u2010Methylsulfone Crosslinked Hydrogels for Cell Encapsulation: Molecular Scale Modulation of Physiochemical Properties"],"prefix":"10.1002","volume":"26","author":[{"given":"Hafiz Syed Usama Bin","family":"Farrukh","sequence":"first","affiliation":[{"name":"INM \u2013 Leibniz Institute For New Materials  Saarbr\u00fccken Germany"},{"name":"Chemistry Department Saarland University  Saarbr\u00fccken Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleeza","family":"Farrukh","sequence":"additional","affiliation":[{"name":"INM \u2013 Leibniz Institute For New Materials  Saarbr\u00fccken Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syuzanna","family":"Hambardzumyan","sequence":"additional","affiliation":[{"name":"INM \u2013 Leibniz Institute For New Materials  Saarbr\u00fccken Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Therese","family":"Steudter","sequence":"additional","affiliation":[{"name":"INM \u2013 Leibniz Institute For New Materials  Saarbr\u00fccken Germany"},{"name":"Chemistry Department Saarland University  Saarbr\u00fccken Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Pearson","sequence":"additional","affiliation":[{"name":"INM \u2013 Leibniz Institute For New Materials  Saarbr\u00fccken Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5725-2135","authenticated-orcid":false,"given":"Ar\u00e1nzazu del","family":"Campo","sequence":"additional","affiliation":[{"name":"INM \u2013 Leibniz Institute For New Materials  Saarbr\u00fccken Germany"},{"name":"Chemistry Department Saarland University  Saarbr\u00fccken 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