{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:27:51Z","timestamp":1791260871915,"version":"4.1.0"},"reference-count":68,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A systematic investigation of various surface coatings on iron oxide nanoparticles (IONPs) was conducted to understand their influence on interfacial interactions, colloidal stability, and magnetic performance. The surface\u2010modified IONPs were synthesized via in situ and physical coating routes using synthetic polymers (polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA), polyethene glycol (PEG), polyethylenimine (PEI)), natural polymers (chitosan (CS), carboxymethyl cellulose (CMC), hyaluronic acid (HA)), small molecules (citric acid (CA), and oleic acid (OA)), and a silane coupling agent (3\u2010aminopropyltriethoxysilane (APTES)). Face\u2010centred cubic spinel\u2010structured magnetite (Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    ) nanoparticles were synthesized with a lattice parameter of 8.356 \u00c5, a particle size of 62 nm, and a saturation magnetization (M\n                    <jats:sub>s<\/jats:sub>\n                    ) of 67.95 A m\n                    <jats:sup>2<\/jats:sup>\n                    kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    . The coating of IONPs was confirmed by X\u2010ray Photoelectron Spectroscopy (XPS)\u00a0and Fourier Transform Infrared (FTIR) spectroscopy, indicating the formation of coordination bonds, hydrogen bonds, and electrostatic interactions between the NPs and the polymeric shell. The coatings substantially reduced agglomeration, thereby decreasing the particle size to 19\u201330 nm, while maintaining nearly superparamagnetic behavior at room temperature. The magnetic behavior was governed by N\u00e9el relaxation for NPs with a size less than 25 nm, whereas larger particles exhibited Brownian relaxation dominance. The relaxation mechanism is responsible for the heating output, measured as the Specific absorption rate (SAR), which provides a useful metric for comparing the heating efficiency of NPs. Induction heating studies carried out under the alternating magnetic field strength of 12.89 kA m\n                    <jats:sup>\u22121<\/jats:sup>\n                    and frequency of 336 kHz revealed that coated IONPs exhibited superior heating performance with improved SAR of 112 to 225 W g\n                    <jats:sup>\u22121<\/jats:sup>\n                    . PEG, CMC, PEI, and APTES\u2010coated IONPs achieved the hyperthermia temperature range of 42\u201346\u00b0C. However, PEG, CMC, and PEI\u2010coated IONPs exhibited N\u00e9el relaxation dominance, which is desirable for in vivo hyperthermia applications. Furthermore, all the coated IONPs (except PEI\u2010IONPs) demonstrated excellent in vitro cytocompatibility (&gt; 80%) with the human embryonic kidney (HEK293) cell line at 2 mg mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    for 72 h. Simulated hyperthermic conditions led to cancer cell lethality, with normal cells being largely viable, suggesting the efficacy of hyperthermia for cancer treatment.\n                  <\/jats:p>","DOI":"10.1002\/mabi.202500632","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T10:16:28Z","timestamp":1774606588000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Surface Functionalization of Iron Oxide Nanoparticles With Polymers and Small Molecules: Synthesis, Characterization, and Evaluation of Magnetic Hyperthermia Performance"],"prefix":"10.1002","volume":"26","author":[{"family":"Mehak","sequence":"first","affiliation":[{"name":"Bio\u2010Interface &amp; Environmental Engineering Lab Department of Biosciences and Bioengineering Indian Institute of Technology Guwahati  Guwahati Assam India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mhonyamo M","family":"Patton","sequence":"additional","affiliation":[{"name":"Nanomagnetism Group Department of Physics National Institute of Technology Nagaland  Dimapur Nagaland India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyoti Prasad","family":"Borah","sequence":"additional","affiliation":[{"name":"Nanomagnetism Group Department of Physics National Institute of Technology Nagaland  Dimapur Nagaland India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajkumar P","family":"Thummer","sequence":"additional","affiliation":[{"name":"Laboratory For Stem Cell Engineering and Regenerative Medicine Department of Biosciences and Bioengineering Indian Institute of Technology Guwahati  Guwahati Assam India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1664-5730","authenticated-orcid":false,"given":"Lalit Mohan","family":"Pandey","sequence":"additional","affiliation":[{"name":"Bio\u2010Interface &amp; Environmental Engineering Lab Department of Biosciences and Bioengineering Indian Institute of Technology Guwahati  Guwahati Assam India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1088\/0022\u20103727\/36\/13\/201"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1369\u20107021(11)70163\u20108"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmmm.2006.10.1156"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.0c03052"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/02648725.2023.2169370"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rineng.2023.101206"},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2019.109838","article-title":"Comparison of Ionic Polymers in the Targeted Drug Delivery Applications as the Coating Materials on the Fe3O4 Nanoparticles","volume":"103","author":"Bekaro\u011flu M. 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