{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T08:10:11Z","timestamp":1774858211083,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["2308085QE157"],"award-info":[{"award-number":["2308085QE157"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013058","name":"Jiangsu Provincial Key Research and Development Program","doi-asserted-by":"publisher","award":["BE2022708"],"award-info":[{"award-number":["BE2022708"]}],"id":[{"id":"10.13039\/501100013058","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The engineering cartilage scaffolds with biomimetic structural features hold critical importance for effective repair and regeneration of damaged cartilage tissue. Recent advancements in 3D printing technology have facilitated the fabrication of multi\u2010layered, gradient scaffolds with precisely controlled macrostructural geometries. However, current 3D\u2010printed scaffolds still fall short of replicating the full spectrum of biomechanical and functional properties inherent to native cartilage. In this study, a 5Gt\u20107Alg\u20103HA composite scaffold featuring vertical\u2010oriented microstructures was fabricated by integrating template\u2010freezing orientation and 3D printing technologies. The influence of vertical\u2010oriented microstructures on the scaffold's multifaceted properties was evaluated through comparative analysis with non\u2010oriented scaffolds in the control group. The results revealed that, compared to non\u2010oriented scaffolds, the vertical\u2010oriented scaffolds exhibited a more uniform and interconnected 3D network structure, higher porosity, more suitable swelling and degradation rates, as well as superior biocompatibility. Notably, significant improvements were observed in the mechanical properties of the vertical\u2010oriented scaffolds. In conclusion, these findings may offer a strategic approach for developing next\u2010generation cartilage scaffolds with biomimetic properties.<\/jats:p>","DOI":"10.1002\/mabi.202500651","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T07:20:03Z","timestamp":1773127203000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Influence of Vertical\u2010Oriented Microstructures on the Properties of 3D\u2010Printed 5Gt\u20107Alg\u20103HA Cartilage Scaffolds"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0309-1212","authenticated-orcid":false,"given":"Xiaofang","family":"Wu","sequence":"first","affiliation":[{"name":"School of Mechatronic Engineering Anhui University of Science and Technology  Huainan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Materials Science and Physics China University of Mining and Technology  Xuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Materials Science and Physics China University of Mining and Technology  Xuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyue","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Materials Science and Physics China University of Mining and Technology  Xuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cunao","family":"Feng","sequence":"additional","affiliation":[{"name":"School of Materials Science and Physics China University of Mining and Technology  Xuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaowei","family":"Li","sequence":"additional","affiliation":[{"name":"School of Materials Science and Physics China University of Mining and Technology  Xuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dekun","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Materials Science and Physics China University of Mining and Technology  Xuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcot.2021.101718"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12938\u2010025\u201001342\u20103"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2022.08.146"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.28.12.125003"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241713374"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.A2400513"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202504057"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2024.07.207"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compositesb.2023.110709"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.124113"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.4c00091"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2023.0344"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.03.009"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.01.006"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2017.0223"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2020.12.009"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9TB02278C"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2021.102426"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics17020153"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymer.2025.128105"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2024.214092"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2022.213052"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics17020153"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c07918"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.36288"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202518948"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtchem.2025.102633"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.8b00523"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomimetics7030131"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2023.137098"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2016.12.017"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2018.05.016"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5TB00383K"}],"container-title":["Macromolecular Bioscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mabi.202500651","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mabi.202500651","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mabi.202500651","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T07:20:25Z","timestamp":1774855225000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mabi.202500651"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/mabi.202500651"],"URL":"https:\/\/doi.org\/10.1002\/mabi.202500651","archive":["Portico"],"relation":{},"ISSN":["1616-5187","1616-5195"],"issn-type":[{"value":"1616-5187","type":"print"},{"value":"1616-5195","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2025-11-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00651"}}