{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:15:39Z","timestamp":1790648139526,"version":"4.1.0"},"reference-count":139,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T00:00:00Z","timestamp":1773532800000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Skin wound healing involves proliferation, inflammation, regeneration, and remodeling. These processes are severely impaired in diabetes due to advanced glycation end\u2010product accumulation, excessive reactive oxygen species, and vascular dysfunction, requiring multifunctional therapeutic and innovative wound care approaches. Thus, many electrospun polymeric matrices were investigated to enhance wound\u2010healing efficacy; however, few studies have examined ZnO NPs embedded multi\u2010component polymeric nanofibers for diabetic wound healing, where infection, oxidative stress, and delayed regeneration persist as major impediments to diabetic wound repair. Addressing these challenges, this study developed a novel therapeutic strategy using electrospun nanofibers of poly(vinyl alcohol)\u2010chitosan\u2010poly(methyl methacrylate) (PVA\u2010Cs\u2010PMMA) integrated with biogenic zinc oxide nanoparticles (Bio\u2010ZnO NPs) synthesized from\n                    <jats:italic>Syzygium guineense<\/jats:italic>\n                    . Comprehensively characterized using UV\u2010vis, FTIR, XRD, TEM, SEM\u2010EDX, and XPS analyses, confirming nanoscale crystalline structure and strong polymer\u2010nanoparticle interactions. Bio\u2010ZnO NPs exhibited potent antibacterial activity against\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (29.38 \u00b1 0.91\u00a0mm) and\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    (27.82 \u00b1 0.95\u00a0mm), alongside strong antioxidant performance (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 11.60\u00a0mg\u00a0mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    , R\n                    <jats:sup>2<\/jats:sup>\n                    = 0.966).\n                    <jats:italic>In vivo<\/jats:italic>\n                    diabetic wound demonstrated accelerated healing (\u226599% closure in 14 days) with enhanced re\u2010epithelialization and collagen deposition, without histopathological abnormalities in major organs. These findings underscore Bio\u2010ZnO NPs@PVA\u2010Cs\u2010PMMA nanofibers as an effective biomaterial with strong potential for advanced diabetic wound management.\n                  <\/jats:p>","DOI":"10.1002\/mabi.70172","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T05:23:21Z","timestamp":1773638601000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Green\u2010Synthesized Bio\u2010ZnO Nanoparticle\u2010Integrated PVA\u2010Chitosan\u2010PMMA Nanofibers Enhanced Antimicrobial and Tissue\u2010Regenerative Diabetic Wound Healing"],"prefix":"10.1002","volume":"26","author":[{"given":"Teshale Ayano","family":"Begeno","sequence":"first","affiliation":[{"name":"College of Chemistry Beijing University of Chemical Technology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tibebu Shiferaw","family":"Kassa","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Advanced Functional Polymer Composites College of Materials Science and Engineering Beijing University of Chemical Technology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tassew Belete","family":"Bahru","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Advanced Functional Polymer Composites College of Materials Science and Engineering Beijing University of Chemical Technology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Shuhuan","sequence":"additional","affiliation":[{"name":"College of Chemistry Beijing University of Chemical Technology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Jialei","sequence":"additional","affiliation":[{"name":"College of Chemistry Beijing University of Chemical Technology  Beijing 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