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In this work, a pH\u2010responsive GA\/Gelatin\/ZnS (Glycyrrhizic Acid\/Gelatin\/Zinc Sulfide) hydrogel that can automatically release drugs was constructed in a facile way. It was fabricated by amide bonds, hydrogen bonds, and metal ion coordination among ZnS nanoparticles, glycyrrhizic acid (GA), and gelatin, which was confirmed by the molecular dynamics (MD) simulations and characterization results. Taking advantage of the pathological microenvironments at the wound site, it can synergize with multi\u2010substance therapies at different stages, thus promoting wound healing. The as\u2010prepared hydrogel can not only exhibit excellent coagulation ability in the hemostatic phase, but also release zinc ion (Zn\n                    <jats:sup>2+<\/jats:sup>\n                    ) and hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) due to the weak acid microenvironment at the wound site, thus boosting inflammatory stage to proliferative phase. Meanwhile, benefit from its good re\u2010epithelialization and angiogenesis properties in proliferative phase, the as\u2010prepared hydrogel can increase collagen deposition during the remodeling phase, thereby accelerating wound healing. It would open a new perspective for effective wound management.\n                  <\/jats:p>","DOI":"10.1002\/mabi.70176","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T06:45:47Z","timestamp":1774421147000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Microenvironment\u2010Driven Closed\u2010Loop Wound Management Based on Glycyrrhizic Acid\/Gelatin\/Zinc Sulfide Hydrogel"],"prefix":"10.1002","volume":"26","author":[{"given":"Shufan","family":"Wan","sequence":"first","affiliation":[{"name":"Key Laboratory of Fermentation Engineering (Ministry of Education) Hubei University of Technology National \u2018111\u2019 Center for Cellular Regulation and Molecular Pharmaceutics Cooperative Innovation Center of Industrial Fermentation (Ministry of Education &amp; Hubei Province) School of Life and Health Sciences Hubei University of Technology Wuhan People's Republic of 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