{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:19:04Z","timestamp":1791235144994,"version":"4.1.0"},"reference-count":196,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2022\/03157\u20107 2022\/16643\u20107"],"award-info":[{"award-number":["2022\/03157\u20107 2022\/16643\u20107"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["2023.02380.BD"],"award-info":[{"award-number":["2023.02380.BD"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Conventional therapies still provide only limited true tissue regeneration for periodontal diseases, particularly periodontitis, which are highly prevalent chronic inflammatory conditions associated with irreversible loss of tooth\u2010supporting tissues and relevant systemic consequences. In this context, hydrogels based on natural polymers have been widely explored in periodontal tissue engineering as biomimetic matrices capable of modulating the inflammatory response, enabling localized delivery of bioactive agents, and offering temporary structural support. This review summarizes recent advances in hydrogels composed of alginate, collagen, chitosan, and other natural or semi\u2010synthetic polymers applied to periodontal regeneration. The influence of polymer origin, crosslinking strategies, physicochemical and rheological properties, and processing approaches, including injectable formulations, self\u2010healing systems, and bioinks for three\u2010dimensional bioprinting, is discussed in relation to cell adhesion, angiogenesis, osteogenesis, and functional restoration of periodontal tissues. Hybrid platforms such as interpenetrating polymer networks, ceramic\u2010reinforced composites, and systems designed for controlled delivery of drugs, growth factors, exosomes, and stem cells are also examined, with emphasis on immunomodulatory and stimuli\u2010responsive designs tailored to the periodontal microenvironment. Despite robust preclinical evidence demonstrating coordinated regeneration of cementum, periodontal ligament, and alveolar bone, major challenges remain. These include the scarcity of well\u2010controlled clinical trials, limitations in standardization, and regulatory barriers to translation.<\/jats:p>","DOI":"10.1002\/mabi.70194","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T09:25:09Z","timestamp":1778837109000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Recent Advances in Natural Polymers\u2010based Hydrogels for Periodontal Regeneration"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0327-4846","authenticated-orcid":false,"given":"Jo\u00e3o de Freitas","family":"Gomes Neto","sequence":"first","affiliation":[{"name":"Graduate Program in Materials Science and Engineering Federal University of S\u00e3o Carlos  S\u00e3o Carlos SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tainara de Paula de Lima","family":"Lima","sequence":"additional","affiliation":[{"name":"Graduate Program in Materials Science and Engineering Federal University of S\u00e3o Carlos  S\u00e3o Carlos SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiza Meurer","family":"Brand","sequence":"additional","affiliation":[{"name":"Department of Morphological Sciences Institute of Basic Health Sciences Federal University of Rio Grande Do Sul  Porto Alegre RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caio Fernando Cardoso","family":"Souza","sequence":"additional","affiliation":[{"name":"i3S Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o Em Sa\u00fade Universidade Do Porto  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5296-5662","authenticated-orcid":false,"given":"Marcelo Lazzaron","family":"Lamers","sequence":"additional","affiliation":[{"name":"Department of Morphological Sciences Institute of Basic Health Sciences Federal University of Rio Grande Do Sul  Porto Alegre RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2761-4929","authenticated-orcid":false,"given":"Pedro L.","family":"Granja","sequence":"additional","affiliation":[{"name":"i3S Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o Em Sa\u00fade Universidade Do Porto  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Antonio","family":"Pessan","sequence":"additional","affiliation":[{"name":"Graduate Program in Materials Science and Engineering Federal University of S\u00e3o Carlos  S\u00e3o Carlos SP Brazil"},{"name":"Department of Materials Engineering Federal University of S\u00e3o Carlos (UFSCar)  S\u00e3o Carlos SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo Henrique","family":"Backes","sequence":"additional","affiliation":[{"name":"Graduate Program in Materials Science and Engineering Federal University of S\u00e3o Carlos  S\u00e3o Carlos SP Brazil"},{"name":"i3S Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o Em Sa\u00fade Universidade Do Porto  Porto Portugal"},{"name":"Department of Materials Engineering Federal University of S\u00e3o Carlos (UFSCar)  S\u00e3o Carlos SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2012.04.022"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym14153192"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2014.0319"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2025.1639170"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2025.1548950"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10517\u2010025\u201006442\u20107"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.4c00220"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.4c01359"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdsr.2021.09.005"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology12070976"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2013.12.006"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25147810"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2024.1384326"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels8100624"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels9030245"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S492274"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.4c01784"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom13040673"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12192335"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12247\u2010025\u201010163\u20109"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15092353"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15041312"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.124876"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.166999"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202403206"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cobme.2025.100615"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics17101256"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2024.1380528"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.70059"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/cre2.70029"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4LP00001C"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.137893"},{"key":"e_1_2_11_34_1","volume-title":"StatPearls","author":"Gasner N. S.","year":"2025"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13506"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/froh.2024.1447019"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8081135"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1590\/1807\u20103107bor\u20102024.vol38.0116"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph22040624"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.id.0000204762.39826.0f"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25147746"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph14050456"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10113242"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/jfb14100503"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtchem.2024.102016"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2024.1411494"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202502299"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2025.1582215"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels11030192"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1080\/00914037.2022.2075872"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nxmate.2025.100825"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.3c00967"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym14153023"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels7040182"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3MH00891F"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.progpolymsci.2017.04.001"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2025.216868"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2025.111695"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c00923"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3TB03070A"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.139418"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.2c03931"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supmat.2023.100045"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-76573-0_18-1"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.780187"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2024.12.019"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.101855"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.2c01440"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bprint.2020.e00080"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomimetics9080480"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2025.112532"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010025\u201003761\u20109"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232213939"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c13830"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.124275"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/1541\u20104337.12494"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.3390\/md19050264"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.135019"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18050989"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2023.07.008"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1088\/1748\u20106041\/11\/6\/065008"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2004.06.044"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.3390\/jfb15080233"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.0c01571"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpolymj.2024.113423"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c17065"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1093\/rb\/rbaf065"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym17152026"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1177\/08853282221079458"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2023.147195"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom13071062"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym15122649"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.630977"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtla.2019.100572"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.144031"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874210601610010347"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4RA01459F"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100045\u20101809144"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100045\u20101809528"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2024.1469733"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2019.10.043"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano10040605"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jds.2023.01.007"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42247\u2010025\u201001114\u20108"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2017.11.016"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1177\/08853282211024164"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sdentj.2023.05.027"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2019.02.024"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6684667"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.858786"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma10060602"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.143205"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906\u2010024\u201004696\u20108"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphy.2018.00124"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym14163430"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2016.08.012"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.142080"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cobme.2022.100373"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3TC02166A"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sdentj.2018.06.002"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diff.2009.03.005"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0131870"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.12.006"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.3390\/md23050199"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.25987"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100043\u20101768591"},{"key":"e_1_2_11_127_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2024.1362482"},{"key":"e_1_2_11_128_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.23318"},{"key":"e_1_2_11_129_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14091978"},{"key":"e_1_2_11_130_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.0c01108"},{"key":"e_1_2_11_131_1","doi-asserted-by":"publisher","DOI":"10.1080\/00914037.2021.1981322"},{"key":"e_1_2_11_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtla.2021.101169"},{"key":"e_1_2_11_133_1","doi-asserted-by":"publisher","DOI":"10.2147\/NSA.S450026"},{"key":"e_1_2_11_134_1","doi-asserted-by":"publisher","DOI":"10.1088\/1758\u20105090\/acab35"},{"key":"e_1_2_11_135_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100044\u20101800826"},{"key":"e_1_2_11_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.asjsur.2024.08.100"},{"key":"e_1_2_11_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.engreg.2020.10.001"},{"key":"e_1_2_11_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.128596"},{"key":"e_1_2_11_139_1","doi-asserted-by":"crossref","unstructured":"J. K.Ghonima M. E.\u2010D.El\u2010Rashidy G.Kotry et\u00a0al. \u201cA Novel Composite Hyaluronic Acid\/Chitosan\/Polyvinyl Alcohol Ternary Hydrogel Scaffold for Periodontal Regeneration: An Experimental Study \u201d PreprintBioRxiv8(2025) https:\/\/doi.org\/10.21203\/rs.3.rs\u20107023827\/v1.","DOI":"10.21203\/rs.3.rs-7023827\/v1"},{"key":"e_1_2_11_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.identj.2025.105088"},{"key":"e_1_2_11_141_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym10111290"},{"key":"e_1_2_11_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2017.06.009"},{"key":"e_1_2_11_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.identj.2025.103852"},{"key":"e_1_2_11_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.170411"},{"key":"e_1_2_11_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2024.101291"},{"key":"e_1_2_11_146_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202001176"},{"key":"e_1_2_11_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceramint.2025.05.253"},{"key":"e_1_2_11_148_1","doi-asserted-by":"publisher","DOI":"10.3390\/md21050299"},{"key":"e_1_2_11_149_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-90966-5_13"},{"key":"e_1_2_11_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2018.01.060"},{"key":"e_1_2_11_151_1","doi-asserted-by":"publisher","DOI":"10.1177\/20417314231190288"},{"key":"e_1_2_11_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2019.01.018"},{"key":"e_1_2_11_153_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5BM00951K"},{"key":"e_1_2_11_154_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27092757"},{"key":"e_1_2_11_155_1","doi-asserted-by":"crossref","unstructured":"A.Vaziri E.Vasheghani Farahani andF.Bagheri \u201cEnzyme Crosslinked Injectable Silk Fibroin\/Tragacanth Gum Bionanocomposite Hydrogels Embedding Bioactive Glass Nanoparticles With Potential for Bone Tissue Engineering \u201d PreprintBioRxiv(2025) https:\/\/doi.org\/10.2139\/ssrn.5709826.","DOI":"10.2139\/ssrn.5709826"},{"key":"e_1_2_11_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rineng.2025.107813"},{"key":"e_1_2_11_157_1","doi-asserted-by":"publisher","DOI":"10.1515\/revce\u20102020\u20100039"},{"key":"e_1_2_11_158_1","doi-asserted-by":"publisher","DOI":"10.56939\/DBR23122p"},{"key":"e_1_2_11_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e17050"},{"key":"e_1_2_11_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2022.01.201"},{"key":"e_1_2_11_161_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.57844"},{"key":"e_1_2_11_162_1","doi-asserted-by":"publisher","DOI":"10.3390\/md17060365"},{"key":"e_1_2_11_163_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13346\u2010024\u201001745\u20100"},{"key":"e_1_2_11_164_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.202400254"},{"key":"e_1_2_11_165_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.29248"},{"key":"e_1_2_11_166_1","doi-asserted-by":"publisher","DOI":"10.3390\/jfb14110545"},{"issue":"3","key":"e_1_2_11_167_1","first-page":"142","article-title":"Animal Models for Testing Biomaterials in Periodontal Regeneration","volume":"4","author":"Sun Q.","year":"2023","journal-title":"Biomaterials Translational"},{"key":"e_1_2_11_168_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.5c01151"},{"key":"e_1_2_11_169_1","doi-asserted-by":"publisher","DOI":"10.20944\/preprints202501.1452.v2"},{"key":"e_1_2_11_170_1","doi-asserted-by":"publisher","DOI":"10.1302\/1358\u2010992X.2025.7.085"},{"key":"e_1_2_11_171_1","doi-asserted-by":"publisher","DOI":"10.1002\/term.3241"},{"key":"e_1_2_11_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2013.07.006"},{"key":"e_1_2_11_173_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4RA06092J"},{"key":"e_1_2_11_174_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2020.0124"},{"key":"e_1_2_11_175_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels9040277"},{"key":"e_1_2_11_176_1","doi-asserted-by":"publisher","DOI":"10.1038\/natrevmats.2016.71"},{"key":"e_1_2_11_177_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25168562"},{"key":"e_1_2_11_178_1","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering12111213"},{"key":"e_1_2_11_179_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmats.2021.708945"},{"key":"e_1_2_11_180_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano12213878"},{"key":"e_1_2_11_181_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.08.029"},{"key":"e_1_2_11_182_1","doi-asserted-by":"publisher","DOI":"10.2174\/0113895575359305241218113847"},{"key":"e_1_2_11_183_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma18092124"},{"key":"e_1_2_11_184_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25245858"},{"key":"e_1_2_11_185_1","doi-asserted-by":"publisher","DOI":"10.55092\/bm20230009"},{"key":"e_1_2_11_186_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels10110693"},{"key":"e_1_2_11_187_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics17111382"},{"key":"e_1_2_11_188_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.202500096"},{"key":"e_1_2_11_189_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2026.150234"},{"key":"e_1_2_11_190_1","doi-asserted-by":"publisher","DOI":"10.48550\/ARXIV.2012.14683"},{"key":"e_1_2_11_191_1","doi-asserted-by":"publisher","DOI":"10.48550\/ARXIV.2101.02267"},{"key":"e_1_2_11_192_1","doi-asserted-by":"crossref","unstructured":"A.Poirier P. L.Griel T.Zinn et\u00a0al. \u201cEnergy Landscape of Sugar Conformation Controls the Sol\u2010to\u2010Gel Transition in Self\u2010Assembled Bola Glycolipid Hydrogels \u201darXiv(2022): 2206.05106.","DOI":"10.1021\/acs.chemmater.2c00580"},{"key":"e_1_2_11_193_1","unstructured":"\u0130. D.K\u00fclc\u00fcandR.Dargazany \u201cMechanical Characterization of Stress Softening in Double Network Hydrogels \u201darXiv(2017): 1712.07459."},{"key":"e_1_2_11_194_1","doi-asserted-by":"crossref","unstructured":"D.KoganandM.Gottlieb \u201cSAOS and LAOS Rheology for Differentiating Chemical and Physical Crosslinking: A Case Study on PVA Hydrogels \u201darXiv(2025): 2510.06720.","DOI":"10.1007\/s00397-025-01522-x"},{"key":"e_1_2_11_195_1","doi-asserted-by":"crossref","unstructured":"P. L.Bourdonnec C.Ferkous L.Communal L.Cipelletti andR.Merindol \u201cDecoupling Dynamics and Crosslink Stability in Supramolecular Hydrogels Using Associative Exchange \u201darXiv(2025): 2508.19937.","DOI":"10.1002\/adma.202516741"},{"key":"e_1_2_11_196_1","unstructured":"G.Tronci H.Ajiro S. J.Russell D. J.Wood andM.Akashi \u201cTuneable Drug\u2010Loading Capability of Chitosan Hydrogels With Varied Network Architectures \u201darXiv(2013): 1310.7461."},{"key":"e_1_2_11_197_1","doi-asserted-by":"crossref","unstructured":"C.Seyrig A.Poirier P.Javier andN.Baccile \u201cInterpenetrated Biosurfactant\u2010Biopolymer Orthogonal Hydrogels: The Biosurfactant's Phase Controls the Hydrogel's Mechanics \u201darXiv(2022): 2212.10987.","DOI":"10.1021\/acs.biomac.2c00319"}],"container-title":["Macromolecular Bioscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mabi.70194","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mabi.70194","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mabi.70194","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T21:14:38Z","timestamp":1783458878000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mabi.70194"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":196,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/mabi.70194"],"URL":"https:\/\/doi.org\/10.1002\/mabi.70194","archive":["Portico"],"relation":{},"ISSN":["1616-5187","1616-5195"],"issn-type":[{"value":"1616-5187","type":"print"},{"value":"1616-5195","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2026-03-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70194"}}