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In the current study, dextran as a hydrophilic polymer was connected to the surface of aminated graphene via pH\u2010sensitive bond to prepare a novel pH\u2010sensitive drug delivery system. Then, curcumin as a chemotherapy drug was loaded onto A\u2010GO\/Dex via \u03c0\u2013\u03c0 interactions and hydrogen bonds to prepare A\u2010GO\/Dex\/Cur with high loading capacity for curcumin (14.9%). The samples were analyzed by various techniques including FT\u2010IR, TGA, TEM, XRD and DLS. A\u2010GO\/Dex\/Cur revealed a pH\u2010dependent drug release profile and possessed higher cytotoxicity and significant anticancer effects on colon cancer cells as compare to free curcumin. The results indicated the prepared pH\u2010responsive polymer nanocomposite could be used as a promising nanocarrier for curcumin delivery in therapy of colon cancer.<\/jats:p>","DOI":"10.1002\/mabi.70197","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T15:27:26Z","timestamp":1779118046000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preparation and in Vitro Evaluation of Polymer Nanocomposite Based on Graphene\/Dextran as a pH\u2010Sensitive Nanocarrier for Delivery of Anticancer Drug"],"prefix":"10.1002","volume":"26","author":[{"given":"Elham","family":"Aram","sequence":"first","affiliation":[{"name":"Department of Polymer Engineering Faculty of Engineering Golestan University  Gorgan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8143-9338","authenticated-orcid":false,"given":"Hossein Ali","family":"Khonakdar","sequence":"additional","affiliation":[{"name":"Department of Polymer Processing Iran Polymer and Petrochemical Institute  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c08602"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.138342"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12291-024-01239-3"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202309464"},{"issue":"4","key":"e_1_2_8_6_1","first-page":"228","article-title":"Inorganic Nanoparticles for Drug Delivery Systems: Design and Challenges","volume":"1","author":"Hasyim D. 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