{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:48:31Z","timestamp":1792597711260,"version":"4.5.0"},"reference-count":147,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002641","name":"Konkuk University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002641","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Driven by recent successful clinical translation, nucleic acid therapeutics are being actively investigated to expand their applications to various diseases, including renal genetic disorders. As life expectancy increases and the burden of renal diseases continues to rise, nucleic acid therapeutics are considered promising alternatives to conventional treatments. This review summarizes key considerations in the design and fabrication of nanocarriers for the systemic delivery of nucleic acid therapeutics to the kidneys. Key aspects of the renal microenvironment are discussed to guide the design of nanocarriers, including conjugates and nanoparticles. This review also covers renal genetic disorders and nucleic acid\u2010based treatment approaches, including small interfering RNAs (siRNAs), clustered regularly interspaced short palindromic repeats (CRISPR) systems, and messenger RNA (mRNA) therapeutics. In particular, recent strategies for kidney\u2010targeted nanocarriers are highlighted, with an emphasis on their efficacy, challenges, and limitations. Perspectives on the design of nanocarriers for systemic nucleic acid delivery to the kidneys are also provided, offering insights into potential therapeutic approaches for renal genetic disorders.<\/jats:p>","DOI":"10.1002\/mabi.70210","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T04:33:16Z","timestamp":1783571596000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Design of Nanocarriers for Kidney Targeted Delivery of Nucleic Acid Therapeutics"],"prefix":"10.1002","volume":"26","author":[{"given":"Jun Hyuk","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Bioscience and Biotechnology Konkuk University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junku","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Bioscience and Biotechnology Konkuk University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sehwan","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Bioscience and Biotechnology Konkuk University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyejung","family":"Mok","sequence":"additional","affiliation":[{"name":"Department of Bioscience and Biotechnology Konkuk University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.10391012"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157\u2010024\u201002603\u20106"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2019.02.003"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.484"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2012020119"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000031219"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.11766"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI165654"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(14)61601\u20109"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2025.09.050"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0RA03133J"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.12.1001"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149\u20102918(02)80075\u20103"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mt.6300240"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2008.200"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkg393"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2309676"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578\u2010018\u20100038\u20103"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3802"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581\u2010021\u201000474\u20108"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201022331\u20109"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13577\u2010025\u201001296\u20107"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2010020199"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000139478.03463.D9"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2013.06.033"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2007.04.025"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.08880914"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mpaic.2018.03.001"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1982.242.3.F207"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581\u2010024\u201000819\u2010z"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-025-01028-y"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.13850"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2012.02.031"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2017.2902"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010025\u201003108\u20104"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00052.2005"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.2c01083"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00022.2012"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00385.2005"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00077.2021"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.37538"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010025\u201003487\u20108"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2021.11.029"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adt3943"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202500595"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2025.113995"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.33520"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882\u2010023\u201003427\u20104"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm\u20102017\u20100256"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102437"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.04.042"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.3390\/jfb15090249"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2020.119455"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12519\u2010016\u20100009\u2010y"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells13080654"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2022.813637"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2024.1395287"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2012.259"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.407"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfad105"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.5414\/CNCS110975"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750\u20101172\u20105\u201028"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.3233\/PGE\u201014086"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1097\u2010149"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(18)32782\u2010X"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2025.08.026"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2011.164"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1710030"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1402686"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2024.12.035"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02870"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2025.102573"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(23)00037-6"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2024.102437"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2409368"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.202200423"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.202400043"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI64401"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep06424"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43856\u2010023\u201000419\u20101"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2017.03.023"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(10)60284\u2010X"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1702752"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1716793"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2204705"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.18688"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(23)01724\u20105"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2400201"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2402478"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00478.2014"},{"key":"e_1_2_13_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44321\u2010024\u201000071\u20109"},{"key":"e_1_2_13_93_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu208"},{"key":"e_1_2_13_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201016605\u2010x"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01309-7"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-65997-1"},{"key":"e_1_2_13_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201022373\u20109"},{"key":"e_1_2_13_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41431\u2010019\u20100537\u20108"},{"key":"e_1_2_13_99_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2034577"},{"key":"e_1_2_13_100_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2035389"},{"key":"e_1_2_13_101_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2307079"},{"key":"e_1_2_13_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473\u20103099(25)00236\u20101"},{"key":"e_1_2_13_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578\u2010021\u201000358\u20100"},{"key":"e_1_2_13_104_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adw0730"},{"key":"e_1_2_13_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201047085\u2010w"},{"key":"e_1_2_13_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201044830\u20101"},{"key":"e_1_2_13_107_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12033-007-9008-5"},{"key":"e_1_2_13_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2024.105954"},{"key":"e_1_2_13_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtm.2024.101333"},{"key":"e_1_2_13_110_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5c01893"},{"key":"e_1_2_13_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010022\u201000947\u20107"},{"key":"e_1_2_13_112_1","doi-asserted-by":"publisher","DOI":"10.1039\/c4cc01620c"},{"key":"e_1_2_13_113_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.0c00763"},{"key":"e_1_2_13_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2023.102067"},{"key":"e_1_2_13_115_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1103573108"},{"key":"e_1_2_13_116_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9NR09347H"},{"key":"e_1_2_13_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2012.43"},{"key":"e_1_2_13_118_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI174722"},{"key":"e_1_2_13_119_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551\u2010024\u201001341\u20100"},{"key":"e_1_2_13_120_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201054475\u20109"},{"key":"e_1_2_13_121_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010024\u201001780\u2010w"},{"key":"e_1_2_13_122_1","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2018.015"},{"key":"e_1_2_13_123_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12274\u2010018\u20102100\u20102"},{"key":"e_1_2_13_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2024.110251"},{"key":"e_1_2_13_125_1","doi-asserted-by":"publisher","DOI":"10.1038\/380364a0"},{"key":"e_1_2_13_126_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI45361"},{"key":"e_1_2_13_127_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI75417"},{"key":"e_1_2_13_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2024.10.020"},{"key":"e_1_2_13_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2018.11.019"},{"key":"e_1_2_13_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.119643"},{"key":"e_1_2_13_131_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201200733"},{"key":"e_1_2_13_132_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12274\u2010021\u20103894\u2010x"},{"key":"e_1_2_13_133_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c05370"},{"key":"e_1_2_13_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2018.03.002"},{"key":"e_1_2_13_135_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm501028c"},{"key":"e_1_2_13_136_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.9b00240"},{"key":"e_1_2_13_137_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.20246qpt20246b20240b"},{"key":"e_1_2_13_138_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.053029"},{"key":"e_1_2_13_139_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.0000000000000458"},{"key":"e_1_2_13_140_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201065799\u20105"},{"key":"e_1_2_13_141_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2020111561"},{"key":"e_1_2_13_142_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.121.000667"},{"key":"e_1_2_13_143_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2025yx1685b1680nt1687"},{"key":"e_1_2_13_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2025.102497"},{"key":"e_1_2_13_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2023.100716"},{"key":"e_1_2_13_146_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep44904"},{"key":"e_1_2_13_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2025.102639"},{"key":"e_1_2_13_148_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2019111160"}],"container-title":["Macromolecular Bioscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mabi.70210","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mabi.70210","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mabi.70210","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T04:17:42Z","timestamp":1785298662000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mabi.70210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":147,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/mabi.70210"],"URL":"https:\/\/doi.org\/10.1002\/mabi.70210","archive":["Portico"],"relation":{},"ISSN":["1616-5187","1616-5195"],"issn-type":[{"value":"1616-5187","type":"print"},{"value":"1616-5195","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-03-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70210"}}